TY - JOUR
T1 - Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia
T2 - A retrospective cohort study
AU - Terradas, Roser
AU - Grau, Santiago
AU - Blanch, Jordi
AU - Riu, Marta
AU - Saballs, Pere
AU - Castells, Xavier
AU - Horcajada, Juan Pablo
AU - Knobel, Hernando
PY - 2012/8/9
Y1 - 2012/8/9
N2 - Introduction: There is scarce evidence on the use of eosinophil count as a marker of outcome in patients with infection. The aim of this study was to evaluate whether changes in eosinophil count, as well as the neutrophil-lymphocyte count ratio (NLCR), could be used as clinical markers of outcome in patients with bacteremia. Methods: We performed a retrospective study of patients with a first episode of community-acquired or healthcare-related bacteremia during hospital admission between 2004 and 2009. A total of 2,311 patients were included. Cox regression was used to analyze the behaviour of eosinophil count and the NLCR in survivors and non-survivors. Results: In the adjusted analysis, the main independent risk factor for mortality was persistence of an eosinophil count below 0.0454·103/uL (HR = 4.20; 95% CI 2.66-6.62). An NLCR value >7 was also an independent risk factor but was of lesser importance. The mean eosinophil count in survivors showed a tendency to increase rapidly and to achieve normal values between the second and third day. In these patients, the NLCR was <7 between the second and third day. Conclusion: Both sustained eosinopenia and persistence of an NLCR >7 were independent markers of mortality in patients with bacteremia.
AB - Introduction: There is scarce evidence on the use of eosinophil count as a marker of outcome in patients with infection. The aim of this study was to evaluate whether changes in eosinophil count, as well as the neutrophil-lymphocyte count ratio (NLCR), could be used as clinical markers of outcome in patients with bacteremia. Methods: We performed a retrospective study of patients with a first episode of community-acquired or healthcare-related bacteremia during hospital admission between 2004 and 2009. A total of 2,311 patients were included. Cox regression was used to analyze the behaviour of eosinophil count and the NLCR in survivors and non-survivors. Results: In the adjusted analysis, the main independent risk factor for mortality was persistence of an eosinophil count below 0.0454·103/uL (HR = 4.20; 95% CI 2.66-6.62). An NLCR value >7 was also an independent risk factor but was of lesser importance. The mean eosinophil count in survivors showed a tendency to increase rapidly and to achieve normal values between the second and third day. In these patients, the NLCR was <7 between the second and third day. Conclusion: Both sustained eosinopenia and persistence of an NLCR >7 were independent markers of mortality in patients with bacteremia.
UR - http://www.scopus.com/inward/record.url?scp=84864971453&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0042860
DO - 10.1371/journal.pone.0042860
M3 - Article
C2 - 22912753
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 8
M1 - e42860
ER -