Environmentally benign and selective synthesis of hybrid pyrazole sulfoxide and sulfone ligands

Organic compounds containing sulfoxide or sulfone moieties are important as commodity chemicals and as pharmaceuticals. This has led to multiple research regarding new methodologies for their preparation. In this manuscript, we report the development of efficient chemical methodologies for the selective oxidation of a pyrazole-alkylthioether ligand to sulfoxide or sulfone ligands. Electrochemical green routes have also been explored not only for rationalizing the selectivity of the chemical oxidation methodology but also to selectively obtain the sulfoxide and sulfone ligands in good yields. © 2013 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.