TY - JOUR
T1 - Enantioselective Synthesis of 3-Heterosubstituted-2-amino-1-ols by Sequential Metal-Free Diene Aziridination/Kinetic Resolution
AU - Giménez-Nueno, Irene
AU - Guasch, Joan
AU - Funes-Ardoiz, Ignacio
AU - Maseras, Feliu
AU - Matheu, M. Isabel
AU - Castillón, Sergio
AU - Díaz, Yolanda
N1 - © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2019/7/8
Y1 - 2019/7/8
N2 - © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim A general protocol for the enantioselective synthesis of 3-heterosubstituted-2-amino-1-ols was developed based on metal- free intramolecular regio- and stereoselective diene aziridination and regioselective opening. Kinetic resolution of the resulting (1′-NR1R2 and 1′-SR)-4-oxazolidinones was performed using ABCs organocatalysts, expanding the application of this methodology.
AB - © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim A general protocol for the enantioselective synthesis of 3-heterosubstituted-2-amino-1-ols was developed based on metal- free intramolecular regio- and stereoselective diene aziridination and regioselective opening. Kinetic resolution of the resulting (1′-NR1R2 and 1′-SR)-4-oxazolidinones was performed using ABCs organocatalysts, expanding the application of this methodology.
KW - ABC catalysts
KW - carbamates kinetic resolution
KW - enantioselectivity
KW - metal-free aziridination
KW - organocatalysis
KW - sphingosine analogues
KW - vinylaziridines synthesis
UR - http://www.mendeley.com/research/enantioselective-synthesis-3heterosubstituted2amino1ols-sequential-metalfree-diene-aziridinationkine
UR - https://www.scopus.com/pages/publications/85072110171
U2 - 10.1002/chem.201902734
DO - 10.1002/chem.201902734
M3 - Article
C2 - 31283057
SN - 0947-6539
VL - 25
SP - 12628
EP - 12635
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 54
ER -