Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health

Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs)
and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS)
for dental hypersensitivity (DH) treatment. These DDS have been scarcely employed in oral health, being the frst time in
case of MOFs loaded with cannabinoids. In vitro experiments using bovine teeth were performed to verify if the drug is
able to reach the dentin, where it can fow to the pulp tissues and exert its analgesic efect; enamel and dentin regions were
analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process
the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS
have been characterized by diferent techniques, and is was demonstrated that DDS is an efcient way to carry the drug
through dental tissues without compromising their structure.