Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii

Luis M. Jara; Pilar Cortés; Germán Bou; Jordi Barbé; Jesús Aranda

doi:10.1128/AAC.04918-14

Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii

Luis M. Jara, Pilar Cortés, Germán Bou, Jordi Barbé, Jesús Aranda

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

19 Citas (Scopus)

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Copyright © 2015, American Society for Microbiology. All Rights Reserved. The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracycline induce SOS-mediated mutagenesis, whereas colistin and meropenem, which are extensively used in clinical therapy, do not.

Idioma original	Inglés
Páginas (desde-hasta)	4318-4320
Publicación	Antimicrobial Agents and Chemotherapy
Volumen	59
N.º	7
DOI	https://doi.org/10.1128/AAC.04918-14
Estado	Publicada - 1 jul 2015

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abstract = "Copyright {\textcopyright} 2015, American Society for Microbiology. All Rights Reserved. The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracycline induce SOS-mediated mutagenesis, whereas colistin and meropenem, which are extensively used in clinical therapy, do not.",

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Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii. / Jara, Luis M.; Cortés, Pilar; Bou, Germán et al.
En: Antimicrobial Agents and Chemotherapy, Vol. 59, N.º 7, 01.07.2015, p. 4318-4320.

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

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AU - Aranda, Jesús

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AB - Copyright © 2015, American Society for Microbiology. All Rights Reserved. The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracycline induce SOS-mediated mutagenesis, whereas colistin and meropenem, which are extensively used in clinical therapy, do not.

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Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii

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