TY - JOUR
T1 - Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update
AU - Bulbena-Cabre, Andrea
AU - Bassir Nia, Anahita
AU - Perez-Rodriguez, M. Mercedes
PY - 2018/9/1
Y1 - 2018/9/1
N2 - © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: We review the existing literature on gene-environment interactions (G×E) and epigenetic changes primarily in borderline personality disorder (BPD) but also in antisocial, schizotypal, and avoidant personality disorders. Recent Findings: Research supports that susceptibility genes to BPD or its underlying traits may be expressed under certain environmental conditions such as physical or childhood sexual abuse. Epigenetic modifications of neurodevelopment- and stress-related genes are suggested to underlie the relationship between early life adversary and borderline personality disorder. Only limited studies have investigated the role of gene-environment interactions and epigenetic changes in the genesis of antisocial, schizotypal, and avoidant personality disorders. Summary: Considering the lack of pharmacological treatment for most personality disorders, the emerging evidence on the critical role of G×E and epigenetic changes in the genesis of personality disorders could help develop more biologically oriented therapeutic approaches. Future studies should explore the potential of this new therapeutic dimension.
AB - © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: We review the existing literature on gene-environment interactions (G×E) and epigenetic changes primarily in borderline personality disorder (BPD) but also in antisocial, schizotypal, and avoidant personality disorders. Recent Findings: Research supports that susceptibility genes to BPD or its underlying traits may be expressed under certain environmental conditions such as physical or childhood sexual abuse. Epigenetic modifications of neurodevelopment- and stress-related genes are suggested to underlie the relationship between early life adversary and borderline personality disorder. Only limited studies have investigated the role of gene-environment interactions and epigenetic changes in the genesis of antisocial, schizotypal, and avoidant personality disorders. Summary: Considering the lack of pharmacological treatment for most personality disorders, the emerging evidence on the critical role of G×E and epigenetic changes in the genesis of personality disorders could help develop more biologically oriented therapeutic approaches. Future studies should explore the potential of this new therapeutic dimension.
KW - Borderline personality disorder
KW - Epigenetic
KW - Gene environment interaction
KW - Genetic
KW - Personality disorder
U2 - 10.1007/s11920-018-0934-7
DO - 10.1007/s11920-018-0934-7
M3 - Review article
C2 - 30094700
SN - 1523-3812
VL - 20
JO - Current Psychiatry Reports
JF - Current Psychiatry Reports
IS - 9
M1 - 74
ER -