TY - JOUR
T1 - Conventional Cancer Screening versus PET/CT in Dermatomyositis/Polymyositis
AU - Selva-O'Callaghan, Albert
AU - Grau, Josep M.
AU - Gámez-Cenzano, Cristina
AU - Vidaller-Palacín, Antonio
AU - Martínez-Gómez, Xavier
AU - Trallero-Araguás, Ernesto
AU - Andía-Navarro, Eduard
AU - Vilardell-Tarrés, Miquel
PY - 2010/6/1
Y1 - 2010/6/1
N2 - Objective: To determine the value of whole-body [18F] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for diagnosing occult malignant disease in patients with myositis compared with broad conventional cancer screening. Methods: We prospectively studied 55 consecutive patients with a recent diagnosis of myositis in 3 teaching hospitals over a 3-year period by whole-body FDG-PET/CT and compared the results with those of conventional cancer screening, which included thoracoabdominal CT, mammography, gynecologic examination, ultrasonography, and tumor marker analysis. Comparisons were made using predictive values and their 95% confidence intervals. Results: A total of 9 of 55 patients were diagnosed with paraneoplastic myositis. FDG uptake was positive in 7 patients (1 false-positive), negative in 44 patients (3 false-negative), and inconclusive in 4 patients. Positive and negative predictive values of FDG-PET/CT for the diagnosis of cancer were 85.7% and 93.8%, respectively. Conventional screening was cancer-positive in 9 patients (2 false-positive) and negative in the remaining 46 patients (2 false-negative). Positive and negative predictive values were 77.8% and 95.7%, respectively. The overall predictive value of broad conventional screening was the same as that of FDG-PET/CT (92.7 vs 92.7). Conclusion: The performance of FDG-PET/CT, a single imaging study, for diagnosing occult malignant disease in patients with myositis was comparable to that of broad conventional screening, which includes multiple tests. © 2010 Elsevier Inc. All rights reserved.
AB - Objective: To determine the value of whole-body [18F] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for diagnosing occult malignant disease in patients with myositis compared with broad conventional cancer screening. Methods: We prospectively studied 55 consecutive patients with a recent diagnosis of myositis in 3 teaching hospitals over a 3-year period by whole-body FDG-PET/CT and compared the results with those of conventional cancer screening, which included thoracoabdominal CT, mammography, gynecologic examination, ultrasonography, and tumor marker analysis. Comparisons were made using predictive values and their 95% confidence intervals. Results: A total of 9 of 55 patients were diagnosed with paraneoplastic myositis. FDG uptake was positive in 7 patients (1 false-positive), negative in 44 patients (3 false-negative), and inconclusive in 4 patients. Positive and negative predictive values of FDG-PET/CT for the diagnosis of cancer were 85.7% and 93.8%, respectively. Conventional screening was cancer-positive in 9 patients (2 false-positive) and negative in the remaining 46 patients (2 false-negative). Positive and negative predictive values were 77.8% and 95.7%, respectively. The overall predictive value of broad conventional screening was the same as that of FDG-PET/CT (92.7 vs 92.7). Conclusion: The performance of FDG-PET/CT, a single imaging study, for diagnosing occult malignant disease in patients with myositis was comparable to that of broad conventional screening, which includes multiple tests. © 2010 Elsevier Inc. All rights reserved.
KW - Cancer
KW - Dermatomyositis
KW - Paraneoplastic
KW - Polymyositis
KW - Positron emission tomography/computed tomography
KW - Screening
U2 - 10.1016/j.amjmed.2009.11.012
DO - 10.1016/j.amjmed.2009.11.012
M3 - Article
SN - 0002-9343
VL - 123
SP - 558
EP - 562
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 6
ER -
