Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: A longitudinal neuroimaging study

M. Cano, I. Martínez-Zalacaín, empty Bernabéu-Sanz, O. Contreras-Rodríguez, R. Hernández-Ribas, E. Via, A. De Arriba-Arnau, V. Gálvez, M. Urretavizcaya, J. Pujol, J. M. Menchón, N. Cardoner, C. Soriano-Mas

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

65 Citas (Scopus)

Resumen

© The Author(s) 2017. Recent research suggests that neuroplastic and neuroinflammatory changes may account for the mode of action of electroconvulsive therapy (ECT), although extant data do not allow for a clear disambiguation between these two hypotheses. Multimodal neuroimaging approaches (for example, combining structural and metabolic information) may help in clarifying this issue. Here we aimed to assess longitudinal changes in (i) regional gray matter (GM) volumes and (ii) hippocampal metabolite concentrations throughout an acute course of bitemporal ECT, as well as (iii) to determine the association between imaging changes and clinical improvement. We assessed 12 patients with treatment-resistant depression (TRD) at four time points (pre-treatment, after the first ECT session, after the ninth ECT session and 15 days after ECT course completion) and 10 healthy participants at two time points, 5 weeks apart. Patients with TRD showed bilateral medial temporal lobe (MTL) and perigenual anterior cingulate cortex volume increases. Left MTL volume increase was associated with (i) a hippocampal N-acetylaspartate concentration decrease, (ii) a hippocampal Glutamate+Glutamine concentration increase and (iii) significant clinical improvement. The observed findings are, in part, compatible with both neuroplastic and neuroinflammatory changes induced by ECT. We postulate that such phenomena may be interrelated, therefore reconciling the neuroplasticity and neuroinflammatory hypotheses of ECT action.
Idioma originalInglés
Número de artículoe1023
PublicaciónTranslational Psychiatry
Volumen7
N.º2
DOI
EstadoPublicada - 7 feb 2017

Huella

Profundice en los temas de investigación de 'Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: A longitudinal neuroimaging study'. En conjunto forman una huella única.

Citar esto