Body composition changes after switching from protease inhibitors to raltegravir: SPIRAL-LIP substudy

Adrian Curran, Esteban Martinez, Maria Saumoy, Luis Del Rio, Manuel Crespo, Maria Larrousse, Daniel Podzamczer, Joaquin Burgos, Montse Lonca, Pere Domingo, Jose Maria Gatell, Esteban Ribera

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Objective: To compare 48-week changes in body fat distribution and bone mineral density (BMD) between patients switching from a ritonavir-boosted protease inhibitor (PI/r) to raltegravir (RAL) and patients continuing with PI/r. Design: Substudy of the prospective, randomized, open-label, multicenter SPIRAL study. Methods: Patients were randomized (1:1) to continue with the PI/r-based regimen or switch to RAL, maintaining the rest of the treatment unchanged. Dual-energy X-ray absorptiometry and computed tomography scans were performed at baseline and after 48 weeks to measure body fat and bone composition, analyzing intragroup and intergroup differences. Results: Eighty-six patients were included and 74 patients (39 RAL, 35 PI/r) completed the substudy. Significant increases in median [interquartile range (IQR)] visceral adipose tissue (VAT) [20.7 (-2.4 to 45.6) cm 2, P=0.002] and total adipose tissue (TAT) [21.4 (-1.3 to 55.4) cm, P=0.013] were seen within the PI/r group. No significant changes in body fat were seen with RAL or between treatment groups. Regarding bone composition, total BMD [0.01 (0 to 0.02) g/cm 2, P=0.002], total hip BMD [0.01 (0 to 0.03) g/cm, P=0.015] and total hip T score [0.12 (-0.05 to 0.21) SD, P=0.004] significantly increased with RAL, with no significant changes within the PI/r group. Differences between treatment groups were significant in femoral neck BMD [0.01 (-0.02 to 0.02) g/cm, P=0.032] and T score [0.01 (-0.18 to 0.18) SD, P=0.016]. Conclusion: Although there were no significant changes in body fat between groups, maintaining a PI/r-based regimen was associated with a significant increase in VAT and TAT. Switching to RAL led to a significant increase in femoral neck BMD when comparing between groups. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Idioma originalInglés
Páginas (desde-hasta)475-481
EstadoPublicada - 20 feb 2012


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