Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

Anna Hernández-Rubio, Arantza Sanvisens, Lucía Barbier-Torres, Rafael Blanes, Laia Miquel, Marta Torrens, Gabriel Rubio, Ferran Bolao, Paola Zuluaga, Daniel Fuster, Fernando Rodríguez de Fonseca, Magí Farré, Robert Muga*, Esther Papasseit, Clara Pérez-Mañá, Lourdes Poyatos, Nuria García-Marchena, Enric Abellí, Antonio Short, Catalina MorantaAna Sion, Lluisa Ortega, Pol Bruguera, Elsa Caballeria, Ana Messeguer, Francina Fonseca, Juan Ignacio Mestre-Pinto, María Alías, Fernando Dinamarca, Francisco Javier Pavón-Morón, Pedro Araos, María Flores-López, Antonia Serrano, Miguel Marcos, Candelaria Martín, Onán Pérez-Hernández, Jorge Manzanares, Lucía Illescas

*Autor correspondiente de este trabajo

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Resumen

INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.

PATIENTS AND METHODS: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.

RESULTS: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.

CONCLUSIONS: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.

Idioma originalInglés
Número de artículo109822
Páginas (desde-hasta)109822
Número de páginas7
PublicaciónDrug Alcohol Depend
Volumen245
DOI
EstadoPublicada - 1 abr 2023

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