Antibacterial Films Based on MOF Composites that Release Iodine Passively or Upon Triggering by Near‐Infrared Light

Xu Han, Gerard Boix, Mateusz Balcerzak, Oscar Hernando Moriones, Mary Cano-Sarabia, Maria Pilar Cortes Garmendia, Neus G. Bastús, Victor Puntes, Montserrat Llagostera Casas, Inhar Imaz, Daniel Maspoch Comamala

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34 Citas (Scopus)

Resumen

Multidrug-resistant bacteria have become a global health problem for which new prophylactic strategies are now needed, including surface-coatings for hospital spaces and medical equipment. This work reports the preparation and functional validation of a metal-organic framework (MOF) based composite for the triggered controlled release of iodine, an antimicrobial element that does not generate resistance. It comprises beads of the iodophilic MOF UiO-66 containing encapsulated gold nanorods (AuNRs) coated with a silica shell. Irradiation of the AuNRs with near-infrared light (NIR) provokes a photothermal effect and the resultant heat actively liberates the iodine. After validating the performance of this composite, it is integrated into a polymer for the development of antibacterial films. This work assesses the adsorption of iodine into these composite films, as well as its passive long-term release and active light-triggered. Finally, this work validates the antibacterial activity of the composite films in vitro against gram-positive and gram-negative bacteria. The findings will surely inform the development of new prophylactic treatments.

Idioma originalInglés
Número de artículo2112902
Número de páginas12
PublicaciónAdvanced Functional Materials
Volumen32
N.º19
DOI
EstadoPublicada - 9 may 2022

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