Animal models for COVID-19

C. Muñoz-Fontela; W.E. Dowling; S.G.P. Funnell; P.-S. Gsell; A.X. Riveros-Balta; R.A. Albrecht; H. Andersen; R.S. Baric; M.W. Carroll; M. Cavaleri; C. Qin; I. Crozier; K. Dallmeier; L. de Waal; E. de Wit; L. Delang; E. Dohm; W.P. Duprex; D. Falzarano; C.L. Finch; M.B. Frieman; B.S. Graham; L.E. Gralinski; K. Guilfoyle; B.L. Haagmans; G.A. Hamilton; A.L. Hartman; S. Herfst; S.J.F. Kaptein; W.B. Klimstra; I. Knezevic; P.R. Krause; J.H. Kuhn; R. Le Grand; M.G. Lewis; W.-C. Liu; P. Maisonnasse; A.K. McElroy; V. Munster; N. Oreshkova; A.L. Rasmussen; J. Rocha-Pereira; B. Rockx; E. Rodríguez; T.F. Rogers; F.J. Salguero; M. Schotsaert; K.J. Stittelaar; A. García-Sastre; J. Segalés

doi:10.1038/s41586-020-2787-6

Animal models for COVID-19

C. Muñoz-Fontela, W.E. Dowling, S.G.P. Funnell, P.-S. Gsell, A.X. Riveros-Balta, R.A. Albrecht, H. Andersen, R.S. Baric, M.W. Carroll, M. Cavaleri, C. Qin, I. Crozier, K. Dallmeier, L. de Waal, E. de Wit, L. Delang, E. Dohm, W.P. Duprex, D. Falzarano, C.L. FinchM.B. Frieman, B.S. Graham, L.E. Gralinski, K. Guilfoyle, B.L. Haagmans, G.A. Hamilton, A.L. Hartman, S. Herfst, S.J.F. Kaptein, W.B. Klimstra, I. Knezevic, P.R. Krause, J.H. Kuhn, R. Le Grand, M.G. Lewis, W.-C. Liu, P. Maisonnasse, A.K. McElroy, V. Munster, N. Oreshkova, A.L. Rasmussen, J. Rocha-Pereira, B. Rockx, E. Rodríguez, T.F. Rogers, F.J. Salguero, M. Schotsaert, K.J. Stittelaar, A. García-Sastre, J. Segalés

Departamento de Sanidad y Anatomía Animales

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

678 Citas (Scopus)

Resumen

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

Idioma original	Inglés
Número de artículo	586
Páginas (desde-hasta)	509-515
Número de páginas	6
Publicación	Nature
DOI	https://doi.org/10.1038/s41586-020-2787-6
Estado	Publicada - 23 sept 2020

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Muñoz-Fontela, C., Dowling, W. E., Funnell, S. G. P., Gsell, P.-S., Riveros-Balta, A. X., Albrecht, R. A., Andersen, H., Baric, R. S., Carroll, M. W., Cavaleri, M., Qin, C., Crozier, I., Dallmeier, K., de Waal, L., de Wit, E., Delang, L., Dohm, E., Duprex, W. P., Falzarano, D., ... Segalés, J. (2020). Animal models for COVID-19. Nature, 509-515. Artículo 586. https://doi.org/10.1038/s41586-020-2787-6

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abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.",

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Muñoz-Fontela, C, Dowling, WE, Funnell, SGP, Gsell, P-S, Riveros-Balta, AX, Albrecht, RA, Andersen, H, Baric, RS, Carroll, MW, Cavaleri, M, Qin, C, Crozier, I, Dallmeier, K, de Waal, L, de Wit, E, Delang, L, Dohm, E, Duprex, WP, Falzarano, D, Finch, CL, Frieman, MB, Graham, BS, Gralinski, LE, Guilfoyle, K, Haagmans, BL, Hamilton, GA, Hartman, AL, Herfst, S, Kaptein, SJF, Klimstra, WB, Knezevic, I, Krause, PR, Kuhn, JH, Le Grand, R, Lewis, MG, Liu, W-C, Maisonnasse, P, McElroy, AK, Munster, V, Oreshkova, N, Rasmussen, AL, Rocha-Pereira, J, Rockx, B, Rodríguez, E, Rogers, TF, Salguero, FJ, Schotsaert, M, Stittelaar, KJ, García-Sastre, A & Segalés, J 2020, 'Animal models for COVID-19', Nature, pp. 509-515. https://doi.org/10.1038/s41586-020-2787-6

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AU - Muñoz-Fontela, C.

AU - Dowling, W.E.

AU - Funnell, S.G.P.

AU - Gsell, P.-S.

AU - Riveros-Balta, A.X.

AU - Albrecht, R.A.

AU - Andersen, H.

AU - Baric, R.S.

AU - Carroll, M.W.

AU - Cavaleri, M.

AU - Qin, C.

AU - Crozier, I.

AU - Dallmeier, K.

AU - de Waal, L.

AU - de Wit, E.

AU - Delang, L.

AU - Dohm, E.

AU - Duprex, W.P.

AU - Falzarano, D.

AU - Finch, C.L.

AU - Frieman, M.B.

AU - Graham, B.S.

AU - Gralinski, L.E.

AU - Guilfoyle, K.

AU - Haagmans, B.L.

AU - Hamilton, G.A.

AU - Hartman, A.L.

AU - Herfst, S.

AU - Kaptein, S.J.F.

AU - Klimstra, W.B.

AU - Knezevic, I.

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AU - Kuhn, J.H.

AU - Le Grand, R.

AU - Lewis, M.G.

AU - Liu, W.-C.

AU - Maisonnasse, P.

AU - McElroy, A.K.

AU - Munster, V.

AU - Oreshkova, N.

AU - Rasmussen, A.L.

AU - Rocha-Pereira, J.

AU - Rockx, B.

AU - Rodríguez, E.

AU - Rogers, T.F.

AU - Salguero, F.J.

AU - Schotsaert, M.

AU - Stittelaar, K.J.

AU - García-Sastre, A.

AU - Segalés, J.

PY - 2020/9/23

Y1 - 2020/9/23

N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

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Animal models for COVID-19

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