Angiogenic factors for planning fetal surveillance in fetal growth restriction and small‐for‐gestational‐age fetuses: A prospective observational study

Erika Bonacina, Manel Mendoza, Alba Farràs, Pablo Garcia‐Manau, Berta Serrano, Ivan Hurtado, Raquel Ferrer‐Oliveras, Lidia Illan, Mireia Armengol‐Alsina, Elena Carreras

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

10 Citas (Scopus)

Resumen

Objective
The aim of this study was to assess the added value of the soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio for adjusting the periodicity of ultrasound examinations in early-onset fetal growth restriction (FGR) and small for gestational age (SGA).

Design
A prospective, observational study.

Setting
Tertiary referral hospital.

Population
One hundred and thirty-four single pregnancies with ultrasonographic estimated fetal weight (EFW) below the 10th centile between 20+0 and 31+6 weeks of gestation with antegrade umbilical artery flow.

Methods
The time from Doppler and sFlt-1/PlGF assessment to delivery was recorded and classified into four ranges:
Main outcome measures
Sensitivity (Sn), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of sFlt-1/PlGF values to predict the time to delivery.

Results
In the SGA cohort, the NPV calculated for an sFlt-1/PlGF cut-off value of 38 was 100% for delivery before 3 weeks, and 98% for delivery before 4 weeks after diagnosis (95% CI 0.89–1.00). In the FGR cohort, the NPV calculated for an sFlt-1/PlGF cut-off value of 38 was 100% for delivery before 2 weeks after diagnosis (95% CI 0.92–1.00). By contrast, more than 50% of cases with an sFlt-1/PlGF value of >85 required an elective delivery before 1 week.

Conclusions
sFlt-1/PlGF values in early-onset SGA and FGR are predictive of the time to delivery and could be used for planning fetal surveillance, by reducing the frequency of ultrasound in cases with sFlt-1/PlGF 85.

Tweetable abstract
sFlt-1/PlGF values in early-onset SGA/FGR could be used in addition to Doppler for planning fetal surveillance.
Idioma originalInglés
Páginas (desde-hasta)1870-1877
Número de páginas8
PublicaciónBJOG: An International Journal of Obstetrics & Gynaecology
Volumen129
N.º11
DOI
EstadoPublicada - oct 2022

Huella

Profundice en los temas de investigación de 'Angiogenic factors for planning fetal surveillance in fetal growth restriction and small‐for‐gestational‐age fetuses: A prospective observational study'. En conjunto forman una huella única.

Citar esto