Acoustic-like dynamics of amorphous drugs in the THz regime

E. A.A. Pogna; C. Rodríguez-Tinoco; M. Krisch; J. Rodríguez-Viejo; T. Scopigno

doi:10.1038/srep02518

Acoustic-like dynamics of amorphous drugs in the THz regime

E. A.A. Pogna, C. Rodríguez-Tinoco, M. Krisch, J. Rodríguez-Viejo, T. Scopigno

Departamento de Física

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

14 Citas (Scopus)

Resumen

The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic X-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.

Idioma original	Inglés
Número de artículo	2518
Publicación	Scientific Reports
Volumen	3
DOI	https://doi.org/10.1038/srep02518
Estado	Publicada - 20 sept 2013

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title = "Acoustic-like dynamics of amorphous drugs in the THz regime",

abstract = "The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic X-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.",

author = "Pogna, {E. A.A.} and C. Rodr{\'i}guez-Tinoco and M. Krisch and J. Rodr{\'i}guez-Viejo and T. Scopigno",

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T1 - Acoustic-like dynamics of amorphous drugs in the THz regime

AU - Pogna, E. A.A.

AU - Rodríguez-Tinoco, C.

AU - Krisch, M.

AU - Rodríguez-Viejo, J.

AU - Scopigno, T.

PY - 2013/9/20

Y1 - 2013/9/20

N2 - The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic X-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.

AB - The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic X-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.

U2 - 10.1038/srep02518

DO - 10.1038/srep02518

M3 - Article

SN - 2045-2322

VL - 3

JO - Scientific Reports

JF - Scientific Reports

M1 - 2518

ER -

Acoustic-like dynamics of amorphous drugs in the THz regime

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