A restricted cafeteria diet ameliorates biometric and metabolic profile in a rat diet-induced obesity model

Alex Subias-Gusils, Noemí Boqué, Antoni Caimari, Josep M. Del Bas, Roger Mariné-Casadó, Montserrat Solanas*, Rosa M. Escorihuela*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

7 Citas (Scopus)

Resumen

The administration of anti-obesity bioactive compounds and/or functional foods in rodents fed energy restriction diets based on chow food can be difficult to interpret. We propose an energy restricted cafeteria (CAF) diet as a dietetic intervention to be combined with other therapies. Postweaning male rats were fed standard chow, CAF diet or 30% energy restricted CAF diet (CAF-R) for 8 weeks. The CAF-R diet lowered energy intake and the increase of body weight and body mass index due to the CAF diet, lead to an intermediate feed efficiency, and dampened the CAF diet-induced alterations on body composition, serum levels of triacylglycerides and NEFAs, and insulin resistance. These effects were associated with diminished Ucp1, Nrf1 and Tfam1 gene expression in brown adipose tissue. In conclusion, the CAF-R diet ameliorated obesity and related metabolic disorders induced by a regular CAF diet, turning it in a useful tool to study anti-obesity compounds.
Idioma originalInglés
Páginas (desde-hasta)767-780
Número de páginas14
PublicaciónInternational Journal of Food Sciences and Nutrition
Volumen72
N.º6
DOI
EstadoPublicada - 2021

Palabras clave

  • Adaptive thermogenesis
  • Body weight gain
  • Cafeteria diet
  • Dietary treatment
  • Energy restriction
  • Metabolic syndrome

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