TY - JOUR
T1 - A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders
AU - Gratacòs, Mònica
AU - Nadal, Marga
AU - Martín-Santos, Rocío
AU - Pujana, Miguel Angel
AU - Gago, Jordi
AU - Peral, Belén
AU - Armengol, Lluís
AU - Ponsa, Immaculada
AU - Miró, Rosa
AU - Bulbena, Antoni
AU - Estivill, Xavier
PY - 2001/8/10
Y1 - 2001/8/10
N2 - Anxiety disorders are complex and common psychiatric illnesses associated with considerable morbidity and social cost. We have studied the molecular basis of the cooccurrence of panic and phobic disorders with joint laxity. We have identified an interstitial duplication of human chromosome 15q24-26 (named DUP25), which is significantly associated with panic/agoraphobia/social phobia/joint laxity in families, and with panic disorder in nonfamilial cases. Mosaicism, different forms of DUP25 within the same family, and absence of segregation of 15q24-26 markers with DUP25 and the psychiatric phenotypes suggest a non-Mendelian mechanism of disease-causing mutation. We propose that DUP25, which is present in 7% control subjects, is a susceptibility factor for a clinical phenotype that includes panic and phobic disorders and joint laxity.
AB - Anxiety disorders are complex and common psychiatric illnesses associated with considerable morbidity and social cost. We have studied the molecular basis of the cooccurrence of panic and phobic disorders with joint laxity. We have identified an interstitial duplication of human chromosome 15q24-26 (named DUP25), which is significantly associated with panic/agoraphobia/social phobia/joint laxity in families, and with panic disorder in nonfamilial cases. Mosaicism, different forms of DUP25 within the same family, and absence of segregation of 15q24-26 markers with DUP25 and the psychiatric phenotypes suggest a non-Mendelian mechanism of disease-causing mutation. We propose that DUP25, which is present in 7% control subjects, is a susceptibility factor for a clinical phenotype that includes panic and phobic disorders and joint laxity.
U2 - 10.1016/S0092-8674(01)00447-0
DO - 10.1016/S0092-8674(01)00447-0
M3 - Article
SN - 0092-8674
VL - 106
SP - 367
EP - 379
JO - Cell
JF - Cell
ER -
