TY - JOUR
T1 - A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae
AU - Corral Sábado, Jordi
AU - Perez Varela, Maria
AU - Gaona Soler, Marc
AU - Campoy Sanchez, Susana
AU - Barbe Garcia, Jordi
AU - Aranda Rodriguez, Jesus
PY - 2026/6/18
Y1 - 2026/6/18
N2 - Klebsiella pneumoniae is an opportunistic pathogen responsible for a wide range of healthcare-associated infections. In a recent work, we identified a novel Major Facilitator Superfamily efflux system in Acinetobacter baumannii, designated SxtPR, which mediates antimicrobial resistance and pathogenicity (M. Gaona, J. Corral, S. Campoy, J. Barbé, et al, Antimicrob Agents Chemother e0071224, 2024, https://doi.org/10.1128/aac.00712-24). Here, we report the identification and characterization of a homologous system in Klebsiella pneumoniae that plays a similar dual role in antimicrobial resistance and virulence.
AB - Klebsiella pneumoniae is an opportunistic pathogen responsible for a wide range of healthcare-associated infections. In a recent work, we identified a novel Major Facilitator Superfamily efflux system in Acinetobacter baumannii, designated SxtPR, which mediates antimicrobial resistance and pathogenicity (M. Gaona, J. Corral, S. Campoy, J. Barbé, et al, Antimicrob Agents Chemother e0071224, 2024, https://doi.org/10.1128/aac.00712-24). Here, we report the identification and characterization of a homologous system in Klebsiella pneumoniae that plays a similar dual role in antimicrobial resistance and virulence.
KW - Klebsiella pneumoniae
KW - LysR-type transcriptional regulator
KW - MFS efflux pump
U2 - 10.1128/aac.01644-25
DO - 10.1128/aac.01644-25
M3 - Article
C2 - 42313100
SN - 0066-4804
VL - 70
SP - e0164425
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 8
M1 - e0164425.
ER -