3R coordination by Fanconi anemia proteins

Gaëtane Macé; Massimo Bogliolo; Jean-Hugues Guervilly; Jean Antoine Dugas du Villard; Filippo Rosselli

doi:10.1016/j.biochi.2005.05.003

3R coordination by Fanconi anemia proteins

Gaëtane Macé, Massimo Bogliolo, Jean-Hugues Guervilly, Jean Antoine Dugas du Villard, Filippo Rosselli

Departamento de Genética y Microbiología

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

20 Citas (Scopus)

Resumen

Fanconi anemia (FA) is a recessive cancer prone syndrome featuring bone marrow failure and hypersensitivity to DNA crosslinks. Nine FA genes have been isolated so far. The biochemical function(s) of the FA proteins remain(s) poorly determined. However, a large consensus exists on the evidence that, to cope with DNA cross-links, a cell needs a functional FA pathway. In this review, we resume current understanding of how the FA pathway works in response to DNA damage and how it is integrated in a complex network of proteins involved in the maintenance of the genetic stability.

Idioma original	Inglés
Páginas (desde-hasta)	647-658
Número de páginas	12
Publicación	Biochimie
Volumen	87
N.º	7
DOI	https://doi.org/10.1016/j.biochi.2005.05.003
Estado	Publicada - jul 2005

ODS de las Naciones Unidas

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title = "3R coordination by Fanconi anemia proteins",

abstract = "Fanconi anemia (FA) is a recessive cancer prone syndrome featuring bone marrow failure and hypersensitivity to DNA crosslinks. Nine FA genes have been isolated so far. The biochemical function(s) of the FA proteins remain(s) poorly determined. However, a large consensus exists on the evidence that, to cope with DNA cross-links, a cell needs a functional FA pathway. In this review, we resume current understanding of how the FA pathway works in response to DNA damage and how it is integrated in a complex network of proteins involved in the maintenance of the genetic stability.",

author = "Ga{\"e}tane Mac{\'e} and Massimo Bogliolo and Jean-Hugues Guervilly and Villard, {Jean Antoine Dugas du} and Filippo Rosselli",

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AU - Bogliolo, Massimo

AU - Guervilly, Jean-Hugues

AU - Villard, Jean Antoine Dugas du

AU - Rosselli, Filippo

PY - 2005/7

Y1 - 2005/7

N2 - Fanconi anemia (FA) is a recessive cancer prone syndrome featuring bone marrow failure and hypersensitivity to DNA crosslinks. Nine FA genes have been isolated so far. The biochemical function(s) of the FA proteins remain(s) poorly determined. However, a large consensus exists on the evidence that, to cope with DNA cross-links, a cell needs a functional FA pathway. In this review, we resume current understanding of how the FA pathway works in response to DNA damage and how it is integrated in a complex network of proteins involved in the maintenance of the genetic stability.

AB - Fanconi anemia (FA) is a recessive cancer prone syndrome featuring bone marrow failure and hypersensitivity to DNA crosslinks. Nine FA genes have been isolated so far. The biochemical function(s) of the FA proteins remain(s) poorly determined. However, a large consensus exists on the evidence that, to cope with DNA cross-links, a cell needs a functional FA pathway. In this review, we resume current understanding of how the FA pathway works in response to DNA damage and how it is integrated in a complex network of proteins involved in the maintenance of the genetic stability.

U2 - 10.1016/j.biochi.2005.05.003

DO - 10.1016/j.biochi.2005.05.003

M3 - Article

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SP - 647

EP - 658

JO - Biochimie

JF - Biochimie

IS - 7

ER -

3R coordination by Fanconi anemia proteins

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