Protein Kinase CK2:Functional Properties in Cell Growth and Neoplasia

Among the hundreds of protein kinases known to date, protein kinase CK2 has been shown to acts as an essential component for cell survival. Compelling evidence strongly supports that CK2 is involved in the regulation of cell proliferation. CK2 activity is increased in tumor cells and its catalytic subunit may act as an oncogene, as suggested by a recent observation in transgenic mice. The present project aims to undersstanding of CK2 functions related to proliferation in normal and cancer cells, with a concerted approach combining complementary expertises.