1. Identification of the high affinity receptors of the clostridial neurotoxins, their subcellular localization and their dynamic association with the cholesterol- and sphingolipid-enriched lipid domains (lipid rafts).
2. Structural and compositional characterization of lipid rafts in different neuronal models and of their role in different events of the neuronal physiology.
3. Determination of the pharmacological kinetics of the Hc-TeTx fragment as a proserotoninergic agent.
4. Determination of the neuroprotective capacity of the Hc-TeTx in degenerative processes associated with mental diseases.
5. Characterization of the neurotrophic action conducted by the Hc-TeTx fragment: evaluation of its therapeutic capacity in the treatment of neurodegenerative diseases.
h-index
1194
Citas
22
Índice h
Se calcula con base en el n.º de publicaciones almacenadas en Pure y citas de Scopus
1985 …2023
Resultados de investigaciones por año
Huella digital
Profundizar en los temas de investigación en los que Jose Aguilera Avila está activo. Estas etiquetas de temas provienen de las obras de esta persona. Juntos, forma una huella digital única.