VIABILITAT DELS EMPELTS RENALS PROVINENTS DE DONANTS EN ASISTÒLIA CONTROLADA (DONANTS TIPUS III DE MAASTRICHT)

Abstract

The national registers document the constant growth of receptors on waiting list for kidney transplant (the vital prognosis of these patients are conditioned by this situation) as well as a certain slowdown of brain death donations. Throughout the country, the potential sources of grafts for transplant have been promoted, especially the living donors and non-heart beating donors._x000D_ Controlled non-heart-beating donation (CNHBD) presents longer warm ischaemia times wich can affect the viability of the organ, causing a greater delayed function of the graft, immunological phenomena and a lower long term graft survival._x000D_ At Germans Trias i Pujol University Hospital (HUGTiP), as well as increasing the activity of living donor transplantation, a program of Controlled non-heart-beating donation Maastricht III type was launched in October 2014._x000D_ This retrospective work (over three years of program) studies the viability of grafts and receptors after CNHBD, recording parameters such as primary graft non-function, delayed graft function, evolution of functional parameters, acute rejection, graft survival, patients survival and complications. We also analyze what factors of the recipient, the donor and the act of the transplant have significantly influenced the viability of grafts and patients._x000D_ In the HUGTiP series, the primary failure of the graft and the mortality of patients is slightly higher than that of the national groups, probably due to the smaller sample size. The delayed graft function is 10-20% better and the evolution of the functional parameters is slightly better. Unlike the national groups, no functioning graft was lost among the live receptors during the follow up. There is a large majority of patients with no major surgical complications and an acceptable rejection rate._x000D_ The results so far endorse the suitability of the CNHBD program at HUGTiP.

Date of Award	5 Nov 2018
Original language	Catalan
Supervisor	Jaume Fernandez Llamazares Rodriguez (Director), Montserrat Araceli Solá Suárez (Director) & Luis Ibarz Servio (Director)