Utilitat dels factors angiogènics en el retard de creixement intrauterí

Abstract

This thesis investigates the role of angiogenic factors in the identification and management of fetal growth restriction (FGR). The first study analyzes the relationship between the sFlt-1/PlGF ratio and different severity stages of early-onset FGR, demonstrating that these biomarkers can accurately distinguish between them. It also confirms that higher sFlt-1/PlGF values are associated with worse perinatal outcomes. The second study, a randomized clinical trial, compares the use of angiogenic factors with fetomaternal Doppler in the management of late-onset FGR, concluding that sFlt-1/PlGF-based management is not inferior to the Doppler strategy and may reduce unnecessary inductions while improving perinatal outcomes. These findings support the incorporation of angiogenic factors into the clinical management of FGR.

Date of Award	20 May 2025
Original language	Catalan
Supervisor	Nerea Maiz Elizaran (Director) & Manel Mendoza Cobaleda (Director)