Animal models have become a useful tool in the study of physiopathological mechanisms responsible for the development of human diseases. They are also interesting for the study of different diagnostic techniques and treatments of these affections. This is due to the fact that animal models have several advantages, such as the possibility to work with healthy and appropriate controls, and also because they allow to reduce the variability factors, such as differences in age, presence of concomitant diseases, and pharmacological treatments._x000D_ As cardiovascular diseases are the main cause of human death in developed countries, the use of animal models in cardiovascular research has considerably increased. At the same time, different diagnostic imaging techniques have been developed for the study of small laboratory animals. These techniques allow the study of normal and abnormal morphology and physiology in rodents, even during foetal life._x000D_ If we want to study animal models of cardiovascular disease, it is absolutely necessary to know first the normal anatomy and physiology of these animals. For this reason, we have studied the normal arterial vascularisation in mice (aorta, brachiocephalic trunk, left common carotid artery, left subclavian artery, right renal artery, and left femoral artery) by means of B-mode and pulsed Doppler high frequency ultrasound, and we have analyzed the microscopic structure of the abdominal aorta and femoral artery. On the other hand, we have studied, by means of imaging techniques, the cardiac morphology of a mice model deficient for SIRT1 protein that would be used as a model of cardiac pathology.
Uso de técnicas de imagen en el fenotipado cardiovascular del ratón
Domínguez Miño, E. A. (Author). 2011
Student thesis: Doctoral thesis
Student thesis: Doctoral thesis