Recent research highlights the significant inter-individual variability observed in both normal aging and Alzheimer's disease (AD), underscoring the urgent need to develop specific end-of-life prognosticators. This study focused on analyzing behavioral differences across age and genotype in APP23 transgenic mice and their C57BL/6 littermates. Male APP23 mice exhibited superior survival rates compared to females and non-transgenic mice, revealing age-related behavioral patterns particularly in stress coping, frailty, and cognitive impairment.The olfactory function of 3xTg-AD and NTg mice was evaluated using the Food Finding Test (FFT), which revealed the presence of early olfactory alterations in male AD mice, further exacerbated by social isolation. A comprehensive behavioral assessment revealed significant cognitive and emotional deficits in 3xTg-AD mice, with females exhibiting more pronounced symptoms than males. These findings are consistent with human data, underscoring the necessity for sex-specific therapeutic interventions. In conclusion, these findings contribute to our understanding of Alzheimer's disease pathology and suggest the potential value of olfactory testing as an early diagnostic tool.
Survival, Behavioral And Food Find Test's Olfactory Signatures In Male and Female Mice with Alzheimer’s disease and Normal Aging Under Naturalistic and Forced Social Isolation
Marin Pardo, D. (Author). 10 Sept 2024
Student thesis: Doctoral thesis
Marin Pardo, D. (Author),
Gimenez-Llort, L. (Director),
10 Sept 2024Student thesis: Doctoral thesis
Student thesis: Doctoral thesis