Study of the intracellular mechanism implicated in the resistance to apoptotic cell death in glioblastoma multiforme.

Abstract

Glioblastoma multiforme, one of the most aggressive and lethal tumors, is characterized by a high apoptosis resistance. This doctoral thesis addresses the biochemical behavior of diverse glioblastoma cells, including primary cultures, after cytotoxic insult. Despite the tumoral heterogeneity a limited activation of the caspase-activated DNase (CAD) is a common trait among glioblastoma cells. The results obtained demonstrate that glioblastoma cells cannot correctly degrade DNA during cell death. This should be taken into consideration in order to design more efficient therapies because glioblastoma cells can release their genomic content during cell death

Date of Award	19 Dec 2014
Original language	English
Awarding Institution	Universitat de Barcelona - Universitat Pompeu Fabra
Supervisor	Victor Jose Yuste Mateos (Director)