REFERENCE DATA FOR BONE MATERIAL STRENGTH INDEX (BMSI) MEASURED BY IMPACT MICROINDENTATION

Abstract

Objective: Impact microindentation (IMI) is a technique that allows the measurement of mechanicalbone tissue resistance in vivo. IMI has proven to provide useful information on the evaluation of skeletal dise­ases, but the effect of age on the bone property that is measured by this technique is unknown. This study aims to analyzethe relationship between age and MIH. _x000D_ Material and methods: Bone Material Strength index (BMSi), IMI's output variable, was measured in 69 healthy women (median age: 49 years, range: 30-81 years) and 19 healthy men (median age: 34 years, range: 24-98 years). The correlation between BMSi and age was analyzed by linear regression. The asso­ciation between BMSi and age was evaluated by ANOVA after adjusting for body mass index. The poten­tial effect of postmenopausal estrogenic depletion on BMSi was studied by comparing the younger vs the older subset of women through a t-student test. _x000D_ Results: Linear regression analysis showed that BMSi was not correlated with age in either men (R'=0.0016, p=0.74) or women (R'=0.076, p=0.25). Similarly, the BMI-adjusted ANOVA model revealed a lack of asso­ciation of BMSi with age in men (p=0.78) and women (p=0.73). Finally, there were not significant diffe­rences on BMSi detected between the younger and the older subset of women (p=0.8). _x000D_ Conclusions: Bone tissue mechanical resistance in healthy individuals is independent of age and postme­nopausal estrogenic depletion.

Date of Award	8 Feb 2019
Original language	English
Supervisor	Adolfo Díez Pérez (Director) & Francesc Xavier Nogues Solan (Director)