This paper is focused on the identification of factors related to students’ retention. This study was undertaken at a private Higher Education Institution called Politecnico Internacional (Bogota, Colombia). Under a descriptive methodological approach data were collected with the use of ad-hoc questionnaires, with a simple of 1487 students, as well as interviews with managers, teachers, students and a focus group. In relation to the student’s retention, results indicate the importance of variables such as quality and profile of the academic program offered. It is also observed the influence of motivational factors and the personal satisfaction in reference to the students’ persistence within the academic program. These two variables, retention and persistence, are characterized in this paper as independent processes, susceptible to study, which interact and have a direct impact on retention in Higher Education.