Modelos de coste-efectividad en la prevención del cáncer de cuello de útero en países en desarrollo

Student thesis: Doctoral thesis


BACKGROUND: Introducing Human Papillomavirus (HPV) vaccination in a national immunization programme is not straightforward and depends on multiple factors, including disease burden, vaccine effectiveness, cost-effectiveness and affordability of the vaccination program. The economic analyses are a common component of the decision process in industrialized countries. However, although cost-effectiveness analyses are increasingly used in less developed countries, the burden of cervical cancer has clearly led the consideration of the HPV vaccine introduction. OBJECTIVE: To assess the health and economic impact of the HPV 16 and 18 vaccination of pre-adolescents girls and to assist decision makers in less developed countries. METHODOLOGY: A series of analyses have been conducted using two models depending on the data available: micro-simulation model and simple cohort model. CONCLUSION: HPV 16 and 18 vaccination would be considered an effective strategy to reduce the health and economic burden of cervical cancer, but the cost-effectiveness depends on some vaccine assumptions such as the efficacy and the duration of protection and mostly on cost, in addition to the ability of the countries to reach girls before the ages at the highest risk of infection.
Date of Award14 Jan 2015
Original languageSpanish
Supervisor Francesc Xavier Bosch i Jose (Director) & Ferran Torres (Tutor)


  • Cost-effectiviness
  • VPH
  • HPV
  • Developing countries

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