Nematode infections, both those highly prevalent and classically located in tropical and subtropical regions of the world and those of universal distribution, have become a growing health problem in industrialized areas such as the United States and Europe. Toxocarosis is a cosmopolitan parasitosis most prevalent in temperate and tropical regions. Anisakiosis is also considered a ubiquitous parasite infestation, prevalent in areas with high consumption of raw or undercooked seafood. Because the Toxocara or Anisakis larvae do not grow or multiply in the accidental human host, in which they are widely distributed throughout all tissues of the body in the first case or primarily the stomach and duodenum in the case of Anisakis, direct identification of the parasite by standard parasitological methods is very difficult. The diagnosis is based on indirect identification of these parasites, mainly by immunological techniques. The use of pure molecules (molecular biology) has revealed that this diagnosis by elements not only indirectly identifies the parasite, but in some cases different antigens express different clinical situations. With the above background and the possibility today of using individual antigens that allow us to establish the molecular diagnosis, the identification of different immunoglobulin isotypes targeted against different antigens could establish a much more robust and effective basis in both the diagnosis and prognosis of certain types of parasitosis that are difficult to identify. From an allergology standpoint, these parasites could be the cause of unusual hypersensitivity reactions.
|Date of Award||24 Oct 2014|
|Supervisor||Juan Luís Quesada Martínez (Director) & Miquel Vilardell Tarres (Director)|