Abstract
The thesis has been planed in two parts. 1. Included two therapeutics studies about duodenal ulcer healing associated with Hp infection. 2. The assessment of efficacy of the diagnosis methods in the diagnosis of infection and posttreatment check-up.IMPACT OF COLLOIDAL BISMUTH SUBCITRATE (CBS) IN THE ERADICATION RATES OF Helicobacter pylori (Hp) INFECTION-ASSOCIATED DUODENAL ULCER (DU) USING A SHORT TREATMENT REGIMEN WITH OMEPRAZOLE AND CLARITHROMYCIN: A RANDOMIZED STUDY. Am J Gastroenterol 1995; 90:718-21.
Objectives: To evaluate the efficacy of a short treatment regimen in Hp eradication UD healing and to asses the impact of colloidal bismuth subcitrate (CBS) in Hp eradication and ulcer healing. Conclusions: The addition of CBS to the double therapy with omeprazole and clarithromycin improves the eradication rate of Hp .This short therapy is a safe, well tolerated combination that achieves a 80,6% eradication rate of Hp and DU healing rates as good as hose achieved by omeprazole 20mg/d when given for 4 wk.
RANDOMIZED CLINICAL TRIAL COMPARING TWO ONE-WEEK TRIPLE THERAPY REGIMENS FOR THE ERADICATION OF HELICOBACTER PYLORI INFECTION AND DUODENAL ULCER HEALING. Am J Gastroenterol 1998; 93:35-38
Objectives: To evaluate if higher doses of omeprazole improve the efficacy of two one-week triple therapy regimens in Hp eradication and DU healing. Conclusions: High rates of both Hp eradication and DU healing were obtained with both short-treatment regimens, which were safe and well-tolerated. CBS seems to be a good alternative to amoxicillin in the triple therapy combining they with omeprazole and clarithromycin. The omeprazole dose does not seem to play a major role in Hp eradication in these therapeutic combinations.
ACCURACY OF AN ENZYME IMMUNOASSAY FOR THE DETECTION OF Helicobacter pylori IN STOOL SPECIMENS IN THE DIAGNOSIS OF INFECTION AND POSTTREATMENT CHECK-UP. Am J Gastroenterol 2000; 95:2200-5
Objectives: To assess the reliability of a newly developed EIA assay for Hp specific antigen detection in stools (HpSA) compared to histology (H), rapid urease test (RUT) and 13C-urea breath test (UBT) to diagnose Hp infection and to evaluate its usefulness to determine Hp status after treatment. Methods: One hundred and eighty eight patients were included. Hp infection was confirmed in all patients by HpSA test in stools, RUT, UBT and H. Patients were defined as positive for Hp if RUT and UBT or H were positive. One hundred and forty two symptomatic patients received eradication treatment and were reassessed 6 weeks after therapy; in 70 of these patient stool samples were also collected at 24 hours and 6 months after finishing eradication treatment. In the post-treatment follow-up UBT was used as gold standard. Conclusions: 1.-The HpSA stools test using a cut-off value of 0.130 may be useful for the primary diagnosis of H. pylori infection, with sensitivity similar to that obtained with other standard tests, but with less specificity. 2.- HpSA test is not useful for early monitoring of treatment efficacy; and 3.- At 6 weeks and at 6 months post-treatment, HpSA test lacks accuracy as compared to UBT to evaluate the outcome of the eradication treatment.
| Date of Award | 16 Oct 2001 |
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| Original language | Spanish |
| Supervisor | Josep Maria Viver Pi-Sunyer (Director) & Joan Monés Xiol (Director) |