Since a few decades ago, Emerging Persistent Pharmaceutical Pollutants (EPPPs) have been introduced as one type of recalcitrant pollutant sources in water. In this study, synthesis and characterization of molecularly imprinted polymer using selective functional monomer for diclofenac and indomethacin removal in aqueous media via batch mode has been done. Next procedure involved was the characterization of molecularly imprinted solid phase extraction using selective functional monomer for removal and recovery of diclofenac and indomethacin from aqueous media. Then the experimental continued with analytical methods for application of molecularly imprinted polymer using selective functional monomer for diclofenac recovery from water and wastewater._x000D_ _x000D_ From the kinetic study, more than 95% of removal was observed for DCF and IDM, with an initial concentration of 5 mg L-1 of DCF and IDM within 3 min, agitated at 25 oC. From the total adsorption study using a cartridge pre-packed with 10 mg of MIP-IDM and MIP-DCF a high adsorption capacity of 600 mg IDM/g MIP and 200 mg DCF/g MIP respectively, were obtained. Scatchard plots were determined to study the homogeneity properties of MIPs finding that MIP-DCF differs to MIP-IDM. Breakthrough curves have been identified during the saturation study using continuous flow mode._x000D_ _x000D_ Fourier transform infrared-attenuated total reflectance (FTIR-ATR) has been used in order to study the functional groups in three kinds of different MIP-DCF which were original MIP-DCF, MIP-DCF loaded and MIP- DCF eluting after 10 th times of regeneration. In order to study the morphology, scanning electron microscopy (SEM) was used. Pre-polymerization has been studied using 1H NMR. The shift in the signal observed has been identified with the interactions between amine of AT group with carboxylic acid on DCF. MIP-DCF was chosen for packing into the HPLC column. For the selectivity study, both MIPs were carried out in batch mode. The results show that MIP with AT as the monomer bind to DCF molecules. _x000D_ _x000D_ For application study, there were three methods has been designed in order to achieved the application objectives for this study. First, the continuous flow mode equipped to UV spectrophotometry detection; second, the optimization of molecularly imprinted solid phase extraction (MISPE) using real water samples; and thirdly, the MIP packed column equipped to high performance liquid chromatography with ultraviolet detection (HPLC-UV) for simultaneous determination. MIP enhance the efficiency in removal and recovery of EPPPs when the MIP has been used as packing media in column._x000D_ _x000D_ As conclusion, the developed MIP works as a good sorbent in DCF and IDM removal. The molecularly imprinted technology has shown to be a promising technology for the removal of EPPPs in water. As conclusion, the developed MIP works as a good sorbent in DCF and IDM removal.
Design and applications of molecularly imprinted polymers for the separation of some pharmaceutical persistent pollutants
Nurlin Abu Samah, N. (Author). 9 Nov 2017
Student thesis: Doctoral thesis
Student thesis: Doctoral thesis