CARACTERIZACIÓN DE LA EXPRESIÓN DE ÁCIDO RIBONUCLEICO MENSAJERO EN DISTINTOS SUBTIPOS HISTOLÓGICOS DE CARCINOMA BASOCELULAR

Abstract

Basal cell carcinomas (BCC) are the most common cancers worldwide and their incidence is increasing annualy. A subset of BCC behaves more aggressively and are associated with a higher risk of recurrence, local tissue destruction, deeper invasion, subclinical spread, morbidity and distant metastasis risk. The molecular basis for the aggressive behavior, for the different clinical and pathological forms of BCC and their response to the treatments available remains to be elucidated. In this study we evaluated 25 BCC (superficial, nodular, morpheaform and infiltrative) to delineate their molecular heterogeneity by means of mRNA expression analysis. We identified 120 immune-related genes linked to immune response with high expression in most of infiltrative CBC, medium expression in superficial CBC and low in morpheaform and nodular. To corroborate these findings we analyzed these 120 genes and discovered that PD-L1 expression was associated with infiltrative BCC samples compared to nodular, superficial, morpheaform and basosquamous BCC (p=0,01). Overall, our results suggest that the PD-1/PD-L1 axis may play an important role in locally infiltrative BCC and provide support for PD-1/PD-L1 blockade.

Date of Award	25 Oct 2018
Original language	Spanish
Supervisor	Aleix Prat Aparicio (Director) & Vicente Garcia Patos Briones (Director)