Cases of fragility fractures have been identified at the emergency room of the Corporació Sanitària i Universitària Parc Taulí de Sabadel. Cases of femur and pelvis fractures have been selected and compared to controls from the same geographical area in respect to medication exposures. The study was developed in two phases, with an initial phase where controls were identified at the same emergency service than cases, which concluded a lack of internal validity of the study likely due to selection bias. A second phase identified the controls from medical records of primary health care in the same geographic area of influence of the hospital, using data from the primary care electronic record. This second phase has concluded an acceptable internal validity through reproducibility of the risks associated with the use of corticosteroids, which have been widely described previously in various environments. Regarding the exposures of interest that were included as objectives of this study, increased risks have been observed associated to chronic exposure to proton pump inhibitors and selective serotonin reuptake inhibitors. Also, increased risks have been observed for exposures to vitamin K antagonists, loop diuretics, inhaled selective beta-2 agonists, inhaled anticholinergics and oral antiplatelet agents.
Date of Award | 2 Feb 2016 |
---|
Original language | Catalan |
---|
Awarding Institution | - Consorci Corporació Sanitària Parc Taulí de Sabadell
|
---|
Supervisor | Dolors Capellà Hereu (Director) & Caridad Pontes Garcia (Director) |
---|
- Side effects
- Bone fragility
Avaluació de la prevalença d'ús de medicaments en pacients que acudeixen a un servei d'urgències d'un hospital amb fractures per fragilitat òssia
Gorgas Torner, M. Q. (Author). 2 Feb 2016
Student thesis: Doctoral thesis
Student thesis: Doctoral thesis