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A Ti-based alloy (Ti 45 Zr 15 Pd 30 Si 5 Nb 5 ) with already proven excellent mechanical and biocompatibility features has been coated with piezoelectric zinc oxide (ZnO) to induce the electrical self-stimulation of cells. ZnO was grown onto the pristine alloy in two different morphologies: a flat dense film and an array of nanosheets. The effect of the combined material on osteoblasts (electrically stimulable cells) was analyzed in terms of proliferation, cell adhesion, expression of differentiation markers and induction of calcium transients. Although both ZnO structures were biocompatible and did not induce inflammatory response, only the array of ZnO nanosheets was able to induce calcium transients, which improved the proliferation of Saos-2 cells and enhanced the expression of some early differentiation expression genes. The usual motion of the cells imposes strain to the ZnO nanosheets, which, in turn, create local electric fields owing to their piezoelectric character. These electric fields cause the opening of calcium voltage gates and boost cell proliferation and early differentiation. Thus, the modification of the Ti 45 Zr 15 Pd 30 Si 5 Nb 5 surface with an array of ZnO nanosheets endows the alloy with smart characteristics, making it capable of electric self-stimulation.
|Number of pages||16|
|Publication status||Published - 1 Apr 2021|
- TiZrPdSiNb alloy
FingerprintDive into the research topics of 'ZnO Nanosheet-Coated TiZrPdSiNb Alloy as a Piezoelectric Hybrid Material for Self-Stimulating Orthopedic Implants'. Together they form a unique fingerprint.
- 1 Finished
Materiales porosos actuados eléctricamente para mejorar la eficiencia energética en dispositivos magnéticos y generación de hidrogeno como vector de energía
Sort Viñas, J., Pellicer Vila, E. M., Baro Marine, M. D., Chen ., Y., Cialone , M., De Rojas Iii , J. C., Guerrero Hernandez, M., Menendez Dalmau, E., Nicolenco ., A., Sireus , V., Fornell Beringues, J., Solsona Mateos, P., Suriñach Cornet, S., Pané Vidal, S. & Robbennolt, S.
1/01/18 → 30/09/21
Project: Research Projects and Other Grants