Zn- and Cd-metallothionein recombinant species from the most diverse phyla may contain sulfide (S2-) ligands

Mercè Capdevila, Jordi Domènech, Ayelén Pagani, Laura Tío, Laura Villarreal, Sílvia Atrian

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65 Citations (Scopus)

Abstract

A sulfide surprise: The analysis of ZnII-, CdII-, and CuI-MT recombinant preparations of metallothioneins (MTs) from many organisms provides clear evidence that sulfide ions are present in nearly all their physiologically stable ZnII-MT and CdII-MT complexes (see picture), but in none of the CuI-MT species. The features of the MT complexes are in good correla(Chemical Equation Presented) tion with those reported for plant and yeast ZnII- or CdII-γ- glutamyl peptides. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
Original languageEnglish
Pages (from-to)4618-4622
JournalAngewandte Chemie - International Edition
Volume44
Issue number29
DOIs
Publication statusPublished - 18 Jul 2005

Keywords

  • Bioinorganic chemistry
  • Cadmium
  • Metallothioneins
  • S ligands
  • Zinc

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