XY-trivalent association and synaptic anomalies in a male carrier of a robertsonian t(13;14) translocation

J. Navarro, F. Vidal, J. Benet, C. Templado, S. Marina, J. Egozcue

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)


Synaptonemal complexes were analysed in 91 pachytenes from a patient carrier of a Robertsonian translocation 45XY, t(13;14). Electron microscopic studies were carried out in 36 pachytenes. In some cases, sequential light mlcroscopy/electron microscopic images were obtained (16/36). As the resolution of the light microscope does not allow an accurate characterization of anomalies, only EM images have been taken into account. Association of the trivalent and the sex vesicle was detected in 8 of 36 pachytenes (22.2%). Synaptic anomalies (25%), fragmentation of synaptonemal complexes (11.1%) or both (2.8%) were seen in 14 of 36 nuclei. According to previous studies, synaptic anomalies may produce a spermatogenic arrest. However, it has been suggested that synaptic anomalies may be the result of process of cell degeneration, and not its cause. The non-random relationship between the sex vesicle and the transloca tion trivalent may result from the tendency of unpaired segments to associate with each other after homology search is relaxed and heterologous synaptic adjustment is allowed. © 1991 Oxford University Press.
Original languageEnglish
Pages (from-to)376-381
JournalHuman Reproduction
Issue number3
Publication statusPublished - 1 Jan 1991


  • Infertility
  • Synaptic anomalies
  • Synaptonemal complex
  • XY-trivalent association


Dive into the research topics of 'XY-trivalent association and synaptic anomalies in a male carrier of a robertsonian t(13;14) translocation'. Together they form a unique fingerprint.

Cite this