Xenotropic murine leukemia virus-related virus (XMRV) in patients with systemic lupus erythematosus

Eva Balada, Jesús Castro-Marrero, Lledó Felip, Miquel Vilardell-Tarrés, Josep Ordi-Ros

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Objectives Xenotropic murine leukemia virus-related virus (XMRV)-specific proviral DNA has been recently detected in peripheral blood mononuclear cells of patients with chronic fatigue syndrome. Since chronic fatigue is commonly reported in patients with systemic lupus erythematosus (SLE) we aimed at testing the presence of this virus in these patients. Methods Ninety-five SLE patients, 45 of whom had a Fatigue Severity Scale score higher than 3, were included. Molecular analyses were performed by PCR from DNA obtained from the whole blood of both SLE patients and 50 healthy controls. Results None of the 145 samples analyzed yielded the specific XMRV PCR product. Conclusions We conclude that XMRV is not detected in blood neither from SLE patients nor from healthy controls. It leads to infer that other environmental and biological triggers (different from XMRV) may account for the increased levels of fatigue over the course of SLE. © Springer Science+Business Media, LLC 2011.
Original languageEnglish
Pages (from-to)584-587
JournalJournal of Clinical Immunology
Volume31
Issue number4
DOIs
Publication statusPublished - 1 Jan 2011

Keywords

  • Chronic fatigue
  • Systemic lupus erythematosus
  • XMRV

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