TY - JOUR
T1 - X-ray-induced synaptonemal complex damage during meiotic prophase in female fetuses of Rattus norvegicus
AU - Pujol, R.
AU - Cusidó, L.
AU - Rubio, A.
AU - Egozcue, J.
AU - Garcia, M.
PY - 1997/10/6
Y1 - 1997/10/6
N2 - The different types of damage (synaptic anomalies, chromosome reorganizations and nucleolar fragmentation) observed in oocytes from female rat fetuses irradiated at 14, 16 and 18 days of gestation (d.g.), respectively, indicates the existence of a special sensitivity at the different stages of prophase to X-rays. At the highest dose (5 Gy), we observed a decrease in some of the synaptonemal complex indicators of chromosomal damage, probably reflecting a selection against cells with the highest degree of chromosome anomalies.
AB - The different types of damage (synaptic anomalies, chromosome reorganizations and nucleolar fragmentation) observed in oocytes from female rat fetuses irradiated at 14, 16 and 18 days of gestation (d.g.), respectively, indicates the existence of a special sensitivity at the different stages of prophase to X-rays. At the highest dose (5 Gy), we observed a decrease in some of the synaptonemal complex indicators of chromosomal damage, probably reflecting a selection against cells with the highest degree of chromosome anomalies.
KW - Genotoxicity
KW - Meiosis
KW - Synaptonemal complex
KW - X-ray
U2 - https://doi.org/10.1016/S0027-5107(97)00115-2
DO - https://doi.org/10.1016/S0027-5107(97)00115-2
M3 - Article
VL - 379
SP - 127
EP - 134
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
SN - 0027-5107
ER -