Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN

Elena Valassi; Richard Feelders; Dominique Maiter; Philippe Chanson; Maria Yaneva; Martin Reincke; Michal Krsek; Miklós Tóth; Susan M. Webb; Alicia Santos; Isabel Paiva; Irina Komerdus; Michael Droste; Antoine Tabarin; Christian J. Strasburger; Holger Franz; Peter J. Trainer; John Newell-Price; John A.H. Wass; Eleni Papakokkinou; Oskar Ragnarsson; A. Ambrogio; G. Aranda; M. Arosio; M. Balomenaki; P. Beck-Peccoz; C. Berr-Kirmair; M. Bolanowski; J. Bollerslev; B. Thierry; D. Carvalho; F. Cavagnini; E. Christ; F. Demtröder; J. Denes; C. Dimopoulou; A. Dreval; T. Dusek; E. Erdinc; J. A. Evang; J. Fazel; S. Fica; E. Ghigo; M. Goth; Y. Greenman; V. Greisa; I. Halperin; F. A. Hanzu; A. Hermus; G. Johannsson; P. Kamenicky; A. Kasperlik-Zaluska; J. Kirchner; K. Darko; I. Kraljevic; A. Kruszynska; I. Lambrescu; S. Lang; A. Luger; N. Marpole; S. Martin; M. Martinie; O. Moros; M. Orbetzova; F. Pecori Giraldi; A. M. Pereira; J. Pickel; V. Pirags; A. D. Reghina; M. Roberts; S. Roerink; O. Roig; C. Rowan; P. Rudenko; M. A. Sahnoun; J. Salvador; H. A. Sigurjonsdottir; T. Skoric Polovina; R. Smith; B. Stachowska; G. Stalla; J. Tőke; E. Ubina; S. Vinay; M. Wagenmakers; S. Werner; J. Young; P. Zdunowski; K. Zopf; S. Zopp; I. Zosin

doi:10.1111/cen.13600

Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN

Elena Valassi, Richard Feelders, Dominique Maiter, Philippe Chanson, Maria Yaneva, Martin Reincke, Michal Krsek, Miklós Tóth, Susan M. Webb, Alicia Santos, Isabel Paiva, Irina Komerdus, Michael Droste, Antoine Tabarin, Christian J. Strasburger, Holger Franz, Peter J. Trainer, John Newell-Price, John A.H. Wass, Eleni PapakokkinouOskar Ragnarsson, A. Ambrogio, G. Aranda, M. Arosio, M. Balomenaki, P. Beck-Peccoz, C. Berr-Kirmair, M. Bolanowski, J. Bollerslev, B. Thierry, D. Carvalho, F. Cavagnini, E. Christ, F. Demtröder, J. Denes, C. Dimopoulou, A. Dreval, T. Dusek, E. Erdinc, J. A. Evang, J. Fazel, S. Fica, E. Ghigo, M. Goth, Y. Greenman, V. Greisa, I. Halperin, F. A. Hanzu, A. Hermus, G. Johannsson, P. Kamenicky, A. Kasperlik-Zaluska, J. Kirchner, K. Darko, I. Kraljevic, A. Kruszynska, I. Lambrescu, S. Lang, A. Luger, N. Marpole, S. Martin, M. Martinie, O. Moros, M. Orbetzova, F. Pecori Giraldi, A. M. Pereira, J. Pickel, V. Pirags, A. D. Reghina, M. Roberts, S. Roerink, O. Roig, C. Rowan, P. Rudenko, M. A. Sahnoun, J. Salvador, H. A. Sigurjonsdottir, T. Skoric Polovina, R. Smith, B. Stachowska, G. Stalla, J. Tőke, E. Ubina, S. Vinay, M. Wagenmakers, S. Werner, J. Young, P. Zdunowski, K. Zopf, S. Zopp, I. Zosin

Department of Medicine

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32 Citations (Scopus)

Abstract

© 2018 John Wiley & Sons Ltd Objective: Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS). Methods: Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed. Results: At baseline, HRQoL did not differ between PIT-CS (n = 293) and ADR-CS (n = 120) on both EuroQoL and CushingQoL. Total CushingQoL score in PIT-CS and ADR-CS was 41 ± 18 and 44 ± 20, respectively (P =.7). At long-time follow-up (>1 year after treatment) total CushingQoL score was however lower in PIT-CS than ADR-CS (56 ± 20 vs 62 ± 23; P =.045). In a regression analysis, after adjustment for baseline age, gender, remission status, duration of active CS, glucocorticoid dependency and follow-up time, no association was observed between aetiology and HRQoL. Remission was associated with better total CushingQoL score (P <.001), and older age at diagnosis with worse total score (P =.01). Depression at diagnosis was associated with worse total CushingQoL score at the last follow-up (P <.001). Conclusion: PIT-CS patients had poorer HRQoL than ADR-CS at long-term follow-up, despite similar baseline scoring. After adjusting for remission status, no interaetiology differences in HRQoL scoring were found. Age and presence of depression at diagnosis of CS may be potential predictors of worse HRQoL regardless of CS aetiology.

Original language	English
Pages (from-to)	787-798
Journal	Clinical Endocrinology
Volume	88
Issue number	6
DOIs	https://doi.org/10.1111/cen.13600
Publication status	Published - 1 Jun 2018

Keywords

Cushing's syndrome
ERCUSYN
health-related quality of life

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10.1111/cen.13600

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Valassi, E., Feelders, R., Maiter, D., Chanson, P., Yaneva, M., Reincke, M., Krsek, M., Tóth, M., Webb, S. M., Santos, A., Paiva, I., Komerdus, I., Droste, M., Tabarin, A., Strasburger, C. J., Franz, H., Trainer, P. J., Newell-Price, J., Wass, J. A. H., ... Zosin, I. (2018). Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN. Clinical Endocrinology, 88(6), 787-798. https://doi.org/10.1111/cen.13600

@article{31fe8bf527cf4d8abb77108e8456b684,

title = "Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN",

abstract = "{\textcopyright} 2018 John Wiley & Sons Ltd Objective: Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS). Methods: Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed. Results: At baseline, HRQoL did not differ between PIT-CS (n = 293) and ADR-CS (n = 120) on both EuroQoL and CushingQoL. Total CushingQoL score in PIT-CS and ADR-CS was 41 ± 18 and 44 ± 20, respectively (P =.7). At long-time follow-up (>1 year after treatment) total CushingQoL score was however lower in PIT-CS than ADR-CS (56 ± 20 vs 62 ± 23; P =.045). In a regression analysis, after adjustment for baseline age, gender, remission status, duration of active CS, glucocorticoid dependency and follow-up time, no association was observed between aetiology and HRQoL. Remission was associated with better total CushingQoL score (P <.001), and older age at diagnosis with worse total score (P =.01). Depression at diagnosis was associated with worse total CushingQoL score at the last follow-up (P <.001). Conclusion: PIT-CS patients had poorer HRQoL than ADR-CS at long-term follow-up, despite similar baseline scoring. After adjusting for remission status, no interaetiology differences in HRQoL scoring were found. Age and presence of depression at diagnosis of CS may be potential predictors of worse HRQoL regardless of CS aetiology.",

keywords = "Cushing's syndrome, ERCUSYN, health-related quality of life",

author = "Elena Valassi and Richard Feelders and Dominique Maiter and Philippe Chanson and Maria Yaneva and Martin Reincke and Michal Krsek and Mikl{\'o}s T{\'o}th and Webb, {Susan M.} and Alicia Santos and Isabel Paiva and Irina Komerdus and Michael Droste and Antoine Tabarin and Strasburger, {Christian J.} and Holger Franz and Trainer, {Peter J.} and John Newell-Price and Wass, {John A.H.} and Eleni Papakokkinou and Oskar Ragnarsson and A. Ambrogio and G. Aranda and M. Arosio and M. Balomenaki and P. Beck-Peccoz and C. Berr-Kirmair and M. Bolanowski and J. Bollerslev and B. Thierry and D. Carvalho and F. Cavagnini and E. Christ and F. Demtr{\"o}der and J. Denes and C. Dimopoulou and A. Dreval and T. Dusek and E. Erdinc and Evang, {J. A.} and J. Fazel and S. Fica and E. Ghigo and M. Goth and Y. Greenman and V. Greisa and I. Halperin and Hanzu, {F. A.} and A. Hermus and G. Johannsson and P. Kamenicky and A. Kasperlik-Zaluska and J. Kirchner and K. Darko and I. Kraljevic and A. Kruszynska and I. Lambrescu and S. Lang and A. Luger and N. Marpole and S. Martin and M. Martinie and O. Moros and M. Orbetzova and {Pecori Giraldi}, F. and Pereira, {A. M.} and J. Pickel and V. Pirags and Reghina, {A. D.} and M. Roberts and S. Roerink and O. Roig and C. Rowan and P. Rudenko and Sahnoun, {M. A.} and J. Salvador and Sigurjonsdottir, {H. A.} and {Skoric Polovina}, T. and R. Smith and B. Stachowska and G. Stalla and J. T{\H o}ke and E. Ubina and S. Vinay and M. Wagenmakers and S. Werner and J. Young and P. Zdunowski and K. Zopf and S. Zopp and I. Zosin",

year = "2018",

month = jun,

day = "1",

doi = "10.1111/cen.13600",

language = "English",

volume = "88",

pages = "787--798",

journal = "Clinical Endocrinology",

issn = "0300-0664",

number = "6",

}

Valassi, E, Feelders, R, Maiter, D, Chanson, P, Yaneva, M, Reincke, M, Krsek, M, Tóth, M, Webb, SM, Santos, A, Paiva, I, Komerdus, I, Droste, M, Tabarin, A, Strasburger, CJ, Franz, H, Trainer, PJ, Newell-Price, J, Wass, JAH, Papakokkinou, E, Ragnarsson, O, Ambrogio, A, Aranda, G, Arosio, M, Balomenaki, M, Beck-Peccoz, P, Berr-Kirmair, C, Bolanowski, M, Bollerslev, J, Thierry, B, Carvalho, D, Cavagnini, F, Christ, E, Demtröder, F, Denes, J, Dimopoulou, C, Dreval, A, Dusek, T, Erdinc, E, Evang, JA, Fazel, J, Fica, S, Ghigo, E, Goth, M, Greenman, Y, Greisa, V, Halperin, I, Hanzu, FA, Hermus, A, Johannsson, G, Kamenicky, P, Kasperlik-Zaluska, A, Kirchner, J, Darko, K, Kraljevic, I, Kruszynska, A, Lambrescu, I, Lang, S, Luger, A, Marpole, N, Martin, S, Martinie, M, Moros, O, Orbetzova, M, Pecori Giraldi, F, Pereira, AM, Pickel, J, Pirags, V, Reghina, AD, Roberts, M, Roerink, S, Roig, O, Rowan, C, Rudenko, P, Sahnoun, MA, Salvador, J, Sigurjonsdottir, HA, Skoric Polovina, T, Smith, R, Stachowska, B, Stalla, G, Tőke, J, Ubina, E, Vinay, S, Wagenmakers, M, Werner, S, Young, J, Zdunowski, P, Zopf, K, Zopp, S & Zosin, I 2018, 'Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN', Clinical Endocrinology, vol. 88, no. 6, pp. 787-798. https://doi.org/10.1111/cen.13600

In: Clinical Endocrinology, Vol. 88, No. 6, 01.06.2018, p. 787-798.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN

AU - Valassi, Elena

AU - Feelders, Richard

AU - Maiter, Dominique

AU - Chanson, Philippe

AU - Yaneva, Maria

AU - Reincke, Martin

AU - Krsek, Michal

AU - Tóth, Miklós

AU - Webb, Susan M.

AU - Santos, Alicia

AU - Paiva, Isabel

AU - Komerdus, Irina

AU - Droste, Michael

AU - Tabarin, Antoine

AU - Strasburger, Christian J.

AU - Franz, Holger

AU - Trainer, Peter J.

AU - Newell-Price, John

AU - Wass, John A.H.

AU - Papakokkinou, Eleni

AU - Ragnarsson, Oskar

AU - Ambrogio, A.

AU - Aranda, G.

AU - Arosio, M.

AU - Balomenaki, M.

AU - Beck-Peccoz, P.

AU - Berr-Kirmair, C.

AU - Bolanowski, M.

AU - Bollerslev, J.

AU - Thierry, B.

AU - Carvalho, D.

AU - Cavagnini, F.

AU - Christ, E.

AU - Demtröder, F.

AU - Denes, J.

AU - Dimopoulou, C.

AU - Dreval, A.

AU - Dusek, T.

AU - Erdinc, E.

AU - Evang, J. A.

AU - Fazel, J.

AU - Fica, S.

AU - Ghigo, E.

AU - Goth, M.

AU - Greenman, Y.

AU - Greisa, V.

AU - Halperin, I.

AU - Hanzu, F. A.

AU - Hermus, A.

AU - Johannsson, G.

AU - Kamenicky, P.

AU - Kasperlik-Zaluska, A.

AU - Kirchner, J.

AU - Darko, K.

AU - Kraljevic, I.

AU - Kruszynska, A.

AU - Lambrescu, I.

AU - Lang, S.

AU - Luger, A.

AU - Marpole, N.

AU - Martin, S.

AU - Martinie, M.

AU - Moros, O.

AU - Orbetzova, M.

AU - Pecori Giraldi, F.

AU - Pereira, A. M.

AU - Pickel, J.

AU - Pirags, V.

AU - Reghina, A. D.

AU - Roberts, M.

AU - Roerink, S.

AU - Roig, O.

AU - Rowan, C.

AU - Rudenko, P.

AU - Sahnoun, M. A.

AU - Salvador, J.

AU - Sigurjonsdottir, H. A.

AU - Skoric Polovina, T.

AU - Smith, R.

AU - Stachowska, B.

AU - Stalla, G.

AU - Tőke, J.

AU - Ubina, E.

AU - Vinay, S.

AU - Wagenmakers, M.

AU - Werner, S.

AU - Young, J.

AU - Zdunowski, P.

AU - Zopf, K.

AU - Zopp, S.

AU - Zosin, I.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - © 2018 John Wiley & Sons Ltd Objective: Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS). Methods: Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed. Results: At baseline, HRQoL did not differ between PIT-CS (n = 293) and ADR-CS (n = 120) on both EuroQoL and CushingQoL. Total CushingQoL score in PIT-CS and ADR-CS was 41 ± 18 and 44 ± 20, respectively (P =.7). At long-time follow-up (>1 year after treatment) total CushingQoL score was however lower in PIT-CS than ADR-CS (56 ± 20 vs 62 ± 23; P =.045). In a regression analysis, after adjustment for baseline age, gender, remission status, duration of active CS, glucocorticoid dependency and follow-up time, no association was observed between aetiology and HRQoL. Remission was associated with better total CushingQoL score (P <.001), and older age at diagnosis with worse total score (P =.01). Depression at diagnosis was associated with worse total CushingQoL score at the last follow-up (P <.001). Conclusion: PIT-CS patients had poorer HRQoL than ADR-CS at long-term follow-up, despite similar baseline scoring. After adjusting for remission status, no interaetiology differences in HRQoL scoring were found. Age and presence of depression at diagnosis of CS may be potential predictors of worse HRQoL regardless of CS aetiology.

AB - © 2018 John Wiley & Sons Ltd Objective: Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS). Methods: Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed. Results: At baseline, HRQoL did not differ between PIT-CS (n = 293) and ADR-CS (n = 120) on both EuroQoL and CushingQoL. Total CushingQoL score in PIT-CS and ADR-CS was 41 ± 18 and 44 ± 20, respectively (P =.7). At long-time follow-up (>1 year after treatment) total CushingQoL score was however lower in PIT-CS than ADR-CS (56 ± 20 vs 62 ± 23; P =.045). In a regression analysis, after adjustment for baseline age, gender, remission status, duration of active CS, glucocorticoid dependency and follow-up time, no association was observed between aetiology and HRQoL. Remission was associated with better total CushingQoL score (P <.001), and older age at diagnosis with worse total score (P =.01). Depression at diagnosis was associated with worse total CushingQoL score at the last follow-up (P <.001). Conclusion: PIT-CS patients had poorer HRQoL than ADR-CS at long-term follow-up, despite similar baseline scoring. After adjusting for remission status, no interaetiology differences in HRQoL scoring were found. Age and presence of depression at diagnosis of CS may be potential predictors of worse HRQoL regardless of CS aetiology.

KW - Cushing's syndrome

KW - ERCUSYN

KW - health-related quality of life

U2 - 10.1111/cen.13600

DO - 10.1111/cen.13600

M3 - Article

SN - 0300-0664

VL - 88

SP - 787

EP - 798

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 6

ER -

Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN

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