Work-related asthma: Diagnosis and prognosis of immunological occupational asthma and work-exacerbated asthma

Xavier Muñoz, M. J. Cruz, V. Bustamante, J. L. Lopez-Campos, E. Barreiro

    Research output: Contribution to journalReview articleResearchpeer-review

    21 Citations (Scopus)


    © 2014 Esmon Publicidad. The incidence and prevalence of asthma are increasing. One reason for this trend is the rise in adult-onset asthma, especially occupational asthma, which is 1 of the 2 forms of work-related asthma. Occupational asthma is defined as asthma caused by agents that are present exclusively in the workplace. The presence of pre-existing asthma does not rule out the possibility of developing occupational asthma. A distinction has traditionally been made between immunological occupational asthma (whether IgE-mediated or not) and nonimmunological occupational asthma caused by irritants, the most characteristic example of which is reactive airway dysfunction syndrome. The other form of work-related asthma is known as work-exacerbated asthma, which affects persons with pre-existing or concurrent asthma that is worsened by work-related factors. It is important to differentiate between the 2 entities because their treatment, prognosis, and medical and social repercussions can differ widely. In this review, we discuss diagnostic methods, treatment, and avoidance/nonavoidance of the antigen in immunological occupational asthma and work-exacerbated asthma.
    Original languageEnglish
    Pages (from-to)396-405
    JournalJournal of Investigational Allergology and Clinical Immunology
    Issue number6
    Publication statusPublished - 1 Jan 2014


    • Irritants
    • Peak expiratory flow
    • Specific inhalation challenge
    • Workplace


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