Wobbly syndrome in an african pygmy hedgehog (Atelerix albiventris): Neuropathological and immunohistochemical studies

Letícia Batelli de Oliveira, Willian Henrique de Magalhães Santos Matheus Vilardo Lóes Moreira, Líslie Caroline Oliveira Stuart, Maria Dolors Pi Castro, Marti Pumarola Batlle, Roselene Ecco

Research output: Contribution to journalArticleResearch

Abstract

A three-year-old female African pygmy hedgehog (Atelerix albiventris), born and domiciled in Brazil. presented apathy, prostration, and difficulty to stay standing. Its parents were siblings but did not present clinical signs related to this condition. As its clinical condition worsened, the animal was euthanized and referred for necropsy. No gross lesions were found in the central nervous system (CNS). Histologically, there was vacuolation with axonal degeneration in the white matter of the CNS and in peripheral nervous tissue. The Kluvver-Barrera (KB) stain confirmed demyelination in vacuolated areas. Immunohistochernistry using several neural markers confirmed astrocytosis and microgliosis associated with vacuolated areas. In addition. there was a mild decrease in the immuno intensity of myelin proteolipid protein (PLP) in these areas. These results suggest a genetic origin of the present demyelination. which resulted in the wobbly syndrome described in this report.

Original languageEnglish
Article number20180742
Pages (from-to)-
Number of pages6
JournalCiência Rural, Santa Maria
Volume49
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Central nervous system
  • Degenerative disease
  • Histopathology
  • Myelopathy
  • Vacuolation

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    Oliveira, L. B. D., Matheus Vilardo Lóes Moreira, W. H. D. M. S., Stuart, L. C. O., Pi Castro, M. D., Pumarola Batlle, M., & Ecco, R. (2019). Wobbly syndrome in an african pygmy hedgehog (Atelerix albiventris): Neuropathological and immunohistochemical studies. Ciência Rural, Santa Maria, 49(1), -. [20180742]. https://doi.org/10.1590/0103-8478cr20180742