Whole-chromosome aneuploidy analysis in human oocytes: Focus on comparative genomic hybridization

A. Obradors, M. Rius, G. Daina, L. Ramos, J. Benet, J. Navarro

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12 Citations (Scopus)

Abstract

The study of aneuploidy in human oocytes, discarded from IVF cycles, has provided a better understanding of the incidence of aneuploidy of female origin and the responsible mechanisms. Comparative genomic hybridization (CGH) is an established technique that allows for the detection of aneuploidy in all chromosomes avoiding artifactual chromosome losses. In this review, results obtained using CGH in single cells (1PB and/or MII oocytes) are included. The results of oocyte aneuploidy rates obtained by CGH from discarded oocytes of IVF patients and of oocyte donors are summarized. Moreover, the mechanisms involved in the aneuploid events, e.g. whether alterations occurred due to first meiotic errors or germ-line mitotic errors are also discussed. Finally, the incidence of aneuploid oocyte production due to first meiotic errors and germ-line mitotic errors observed in oocytes coming from IVF patients and IVF oocyte donors was assessed. Copyright © 2011 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)119-126
JournalCytogenetic and Genome Research
Volume133
Issue number2-4
DOIs
Publication statusPublished - 1 Apr 2011

Keywords

  • Aneuploidy
  • Comparative genomic hybridization
  • Meiotic errors
  • Oocyte

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