TY - JOUR
T1 - Weight loss in prepubertal obese children is associated with a decrease in adipocyte fatty-acid-binding protein without changes in lipocalin-2
T2 - A 2-year longitudinal study
AU - Corripio, Raquel
AU - Gónzalez-Clemente, José Miguel
AU - Pérez-Sánchez, Jacobo
AU - Näf, Sílvia
AU - Gallart, Lluís
AU - Nosàs, Ramon
AU - Vendrell, Joan
AU - Caixàs, Assumpta
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Context: Lipocalin-2 and adipocyte fatty-acid-binding protein (A-FABP or FABP4) are adipokines potentially involved in the pathophysiology of obesity and metabolic syndrome in adults. In children, they have been scarcely studied. Objective: To analyze lipocalin-2 and A-FABP circulating levels before and after 2 years of a dieting and lifestyle intervention in a prepubertal obese cohort. Design and setting: Case - control study with a prospective follow-up of cases for 2 years in our referral pediatric endocrine outpatient center. Patients and methods: Seventy-three prepubertal obese children, 8.03±1.08-years old, and 47 age- and gender-matched lean controls were studied. Anthropometric parameters, blood pressure, fasting oral glucose tolerance test, homeostatic model insulin resistance index (HOMA-IR), lipid profile, lipocalin-2, and A-FABP were evaluated.Weight loss was considered if z-score body mass index (BMI) decreased at least 0.5 S.D. Results: At baseline, lipocalin-2 and A-FABP were higher in prepubertal obese children than those in lean controls (P<0.001). A-FABP showed a gradual increase, according to the obesity degree (r 2=0.632; P<0.001). After 2 years, obese patients who lost weight showed a decrease in A-FABP (a mean 2% reduction in BMI was associated with a mean 29% decrease in A-FABP (P<0.001)) without changes in lipocalin-2 levels. Regression model analysis adjusted by age, sex, BMI, and HOMA showed that A-FABP was lower in males (β=K5.77 (CI 95%: -9.7; -1.84)) and was modified by BMI (β=2.7 (CI 95%: 1.77-3.62), r2=0.659). Lipocalin-2 was not modified by any of these variables. Conclusions: Prepubertal obese children show high plasma lipocalin-2 and A-FABP levels, but only A-FABP is influenced by weight loss.
AB - Context: Lipocalin-2 and adipocyte fatty-acid-binding protein (A-FABP or FABP4) are adipokines potentially involved in the pathophysiology of obesity and metabolic syndrome in adults. In children, they have been scarcely studied. Objective: To analyze lipocalin-2 and A-FABP circulating levels before and after 2 years of a dieting and lifestyle intervention in a prepubertal obese cohort. Design and setting: Case - control study with a prospective follow-up of cases for 2 years in our referral pediatric endocrine outpatient center. Patients and methods: Seventy-three prepubertal obese children, 8.03±1.08-years old, and 47 age- and gender-matched lean controls were studied. Anthropometric parameters, blood pressure, fasting oral glucose tolerance test, homeostatic model insulin resistance index (HOMA-IR), lipid profile, lipocalin-2, and A-FABP were evaluated.Weight loss was considered if z-score body mass index (BMI) decreased at least 0.5 S.D. Results: At baseline, lipocalin-2 and A-FABP were higher in prepubertal obese children than those in lean controls (P<0.001). A-FABP showed a gradual increase, according to the obesity degree (r 2=0.632; P<0.001). After 2 years, obese patients who lost weight showed a decrease in A-FABP (a mean 2% reduction in BMI was associated with a mean 29% decrease in A-FABP (P<0.001)) without changes in lipocalin-2 levels. Regression model analysis adjusted by age, sex, BMI, and HOMA showed that A-FABP was lower in males (β=K5.77 (CI 95%: -9.7; -1.84)) and was modified by BMI (β=2.7 (CI 95%: 1.77-3.62), r2=0.659). Lipocalin-2 was not modified by any of these variables. Conclusions: Prepubertal obese children show high plasma lipocalin-2 and A-FABP levels, but only A-FABP is influenced by weight loss.
UR - http://www.scopus.com/inward/record.url?scp=78649853126&partnerID=8YFLogxK
U2 - 10.1530/EJE-10-0408
DO - 10.1530/EJE-10-0408
M3 - Artículo
C2 - 20870707
AN - SCOPUS:78649853126
VL - 163
SP - 887
EP - 893
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 6
ER -