Ways forward for tolerance-inducing cellular therapies- An afactt perspective

Anja ten Brinke, Marc Martinez-Llordella, Nathalie Cools, Catharien M.U. Hilkens, S. Marieke Van Ham, Birgit Sawitzki, Edward K. Geissler, Giovanna Lombardi, Piotr Trzonkowski, Eva Martinez-Caceres

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23 Citations (Scopus)


© 2019 ten Brinke, Martinez-Llordella, Cools, Hilkens, van Ham, Sawitzki, Geissler, Lombardi, Trzonkowski and Martinez-Caceres. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.
Original languageEnglish
Article number181
JournalFrontiers in Immunology
Publication statusPublished - 1 Jan 2019


  • Autoimmunity
  • Cell therapy
  • Clinic
  • Dendritic cells
  • Immunomonitoring
  • Regulatory T cells
  • Tolerance
  • Transplantation


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