Viral load is not a prognostic factor in LSIL

Francesc Alameda, Gemma Mancebo, Sergi Mojal, Lara Pijuan, Belén Lloveras, Emilia Romero, Inmaculada Soler, Mercè Bosch, Amparo Quiñonero, Fernando Larrazabal, Ramón Carreras, Sergi Serrano

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To study the HPV viral load (VL) in the prediction of the persistence and/or progression in LSIL cases. Study design: Prospective study. 102 consecutive cases diagnosed as LSIL in 2006 with follow-ups at 6, 12 and 24 months subsequent to diagnosis. Method: Liquid based cytology (ThinPrep®, Hologic, Malborough, MA, USA), for the cytological study. Hybrid Captute II Test (HCII-HR, Quiagen, Hilden, Germany), for the determination of the presence or absence of High-Risk HPV. Results: 87 of the 102 cases studied were HR-HPV positive (85.3%). The presence or progression was detected in 54%, 42% and 33.35% of the cases in the first, second and third controls respectively. No lesion was demonstrated in 46%, 57% and 66.7% of the cases at first, second and third controls respectively. 19 cases progressed to HSIL; 11 of which were detected on the first control, 6 on the second and 2 on the third. The sensitivity of the VL for detecting HSIL never exceeded 89%, with a specificity always inferior to 40%. Conclusion: The VL determined by the HC2 method is not a useful indicator of prognosis in the follow-up of LSIL cases. © 2011 SEAP y SEC.
Original languageEnglish
Pages (from-to)139-144
JournalRevista Espanola de Patologia
Volume44
Issue number3
DOIs
Publication statusPublished - 1 Jul 2011

Keywords

  • Follow-up
  • LSIL
  • Persistence
  • Progression
  • Viral load

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