Vibrating tail, digging, body/face interaction, and lack of barbering: Sex-dependent behavioral signatures of social dysfunction in 3xTg-AD mice as compared to mice with normal aging

Virginia Torres-Lista, Lydia Giménez-Llort

Research output: Contribution to journalArticleResearch

3 Citations (Scopus)

Abstract

© 2019 - IOS Press and the authors. All rights reserved. Modeling of Alzheimer's disease (AD), classically focused on the subject-environment interaction, foresees current social neuroscience efforts as improving the predictive validity of new strategies. Here we studied social functioning among congeners in 13-14-month-old mice with normal aging in naturalistic and experimental conditions and depicted behavioral signatures of dysfunction in age-matched 3xTg-AD mice. The most sensitive variables were vibrating tail, digging, body/face and self-grooming, that can be easily used in housing routines and the assessment of strategies. Sex-specific signatures (vibrating tail, digging, and grooming) defined female 3xTg-AD mice ethogram. All animals sleep huddled while barbering was only found in females with normal aging.
Original languageEnglish
Pages (from-to)969-977
JournalJournal of Alzheimer's Disease
Volume69
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Barbering
  • Behavioral and psychological symptoms of dementia
  • Dalila effect
  • Digging
  • Ethogram markers
  • Monitoring
  • Sleeping behavior
  • Social behavior
  • Social Interaction Test
  • Tube-dominance test

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