Ventro-Striatal Reductions Underpin Symptoms of Hyperactivity and Impulsivity in Attention-Deficit/Hyperactivity Disorder

Susanna Carmona, Erika Proal, Elseline A. Hoekzema, Juan Domingo Gispert, Marisol Picado, Irene Moreno, Juan Carlos Soliva, Anna Bielsa, Mariana Rovira, Joseph Hilferty, Antonio Bulbena, Miquel Casas, Adolf Tobeña, Oscar Vilarroya

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69 Citations (Scopus)

Abstract

Background: Models of attention-deficit/hyperactivity disorder (ADHD) classically emphasize the relevance of executive processes and, recently, reward circuits. The neural bases of reward processes have barely been explored in relation to this disorder, in contrast to extensive neuroimaging studies that examine executive functions in patients with ADHD. To our knowledge, no previous studies have analyzed the volume of the ventral striatum, a key region for reward processes in ADHD children. Methods: We used a manual region-of-interest approach to examine whether there were volumetric differences in the ventral striatum of ADHD children. Forty-two children/adolescents with ADHD (ages 6-18), and 42 healthy control subjects matched on age, gender, and handedness were selected for the study. Results: The ADHD children presented significant reductions in both right and left ventro-striatal volumes (t = 3.290, p = .001; and t = 3.486, p = .001, respectively). In addition, we found that the volume of the right ventral striatum negatively correlated with maternal ratings of hyperactivity/impulsivity (r = -.503, p = .003). Conclusions: Our study provides neuroanatomical evidence of alterations in the ventral striatum of ADHD children. These findings coincide with previous explicative models as well as with recent reports in behavioral and functional neuroimaging studies. Furthermore, the negative correlations we observed strongly uphold the relation between the ventral striatum and symptoms of hyperactivity/impulsivity. © 2009 Society of Biological Psychiatry.
Original languageEnglish
Pages (from-to)972-977
JournalBiological Psychiatry
Volume66
Issue number10
DOIs
Publication statusPublished - 15 Nov 2009

Keywords

  • Accumbens
  • ADHD
  • attention-deficit/hyperactivity disorder
  • delay aversion
  • reward
  • ventral striatum

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