Vascular factors predict polyneuropathy in a non-diabetic elderly population

Marzia Baldereschi, Marco Inzitari, Antonio Di Carlo, Francesca Bovis, Stefania Maggi, Antonio Capurso, Vincenzo Solfrizzi, Francesco Panza, Emanuele Scafato, Domenico Inzitari, L. Amaducci, G. Farchi, L. Galluzzo, C. Gandin, V. Lepore, P. Livrea, L. Motta, G. Carnazzo, M. Motta, P. BentivegnaS. Bonaiuto, G. Cruciani, D. Postacchini, C. Gandolfo, M. Conti, N. Canal, M. Franceschi, G. Scarlato, L. Candelise, E. Scapini, F. Rengo, P. Abete, F. Cacciatore, G. Enzi, L. Battistin, G. Sergi, G. Crepaldi, N. Minicucci, M. Noale, F. Grigoletto, E. Perissinotto, P. Carbonin

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10 Citations (Scopus)


We prospectively examined whether vascular factors are related to an increased incidence of Chronic Idiopathic Distal Symmetric Neuropathy (CI-DSN) in a non-diabetic elderly population. In 8 Italian municipalities, 2,512 men and women without both diabetes and CI-DSN at baseline are examined. Potential effect of vascular factors was estimated by regressing new onset CI-DSN on the occurrence of several vascular diseases and risk factors. Multivariate relative risks of CI-DSN were estimated by Cox proportional hazards models. After 3.8 (±2.4) years of follow-up, we documented 51 incident CI-DSN cases. At univariate analysis, age, comorbidity, waist circumference, leg length, peripheral artery disease, and coronary heart disease proved to increase the risk of developing CI-DSN. By multivariate analyses, only age (RR = 1.08; 95 % CI, 1.02-1.14), leg length (RR = 1.05; 95 % CI, 1.01-1.1) and peripheral artery disease (RR = 2.75; 95 % CI, 1.15-6.56) proved significant predictors of CI-DSN. Separate analyses by gender show that age is an independent predictor of CI-DSN both in men and in women, while PAD predicts the disease only in men, together with body height. Incidence of CI-DSN is higher in individuals carrying vascular conditions. In men, the presence at baseline of peripheral artery disease is associated with a threefold increase in the risk of developing CI-DSN. The incidence of neuropathy in non-diabetic individuals is associated with potentially modifiable vascular factors. © 2012 Springer-Verlag.
Original languageEnglish
Pages (from-to)955-962
JournalNeurological Sciences
Issue number6
Publication statusPublished - 1 Jun 2013


  • Epidemiology
  • Non-diabetic polyneuropathy
  • Peripheral neuropathies
  • Polyneuropathy


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