Variation of the prion gene in chimpanzees and its implication for prion diseases

M. Soldevila, A. M. Andrés, A. Blancher, F. Calafell, M. Ordoñez, J. Aramburu, J. Bertranpetit, Marti Pumarola Batlle, Baldomero Oliva Miguel

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8 Citations (Scopus)

Abstract

In humans, familial prion diseases are linked to mutations in the PRNP gene. We have sequenced part of this gene in a large sample of common chimpanzee, Pan troglodytes (n=130 chromosomes). No variation in codons 129 and 219 has been observed: all chimpanzees were homozygous for the Met allele, which in humans increases susceptibility to Creutzfeldt-Jakob disease. We found two sequence variants: one is a synonymous polymorphism unique to the chimpanzee at codon 226, TAC to TAT (Y), with a TAC allele frequency of 80.6%; the other is a non-synonymous change at codon 148 (R148H) that falls in the target epitope for some common commercial antibodies used for prion diagnostics, and is highly conserved across species. The pathogenicity of this mutation is still unknown. © 2003 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)157-160
JournalNeuroscience Letters
Volume355
DOIs
Publication statusPublished - 30 Jan 2004

Keywords

  • Chimpanzee
  • Codon 129
  • Codon 148
  • Creutzfeldt-Jakob disease
  • PRNP
  • Polymorphism
  • Prion
  • Prionics test

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