Value of differential quantitative blood cultures in the diagnosis of catheter-related sepsis

J. A. Capdevila, A. M. Planes, M. Palomar, I. Gasser, B. Almirante, A. Pahissa, E. Crespo, J. M. Martínez-Vázquez

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183 Citations (Scopus)

Abstract

A prospective study was performed to assess the value of differential quantitative blood cultures in the diagnosis of catheter-related sepsis when this condition is suspected on clinical grounds and to establish a reliable discriminative value for application without removal of the inserted catheter. A total of 107 central venous catheters from 64 patients were used for the study. Blood was obtained simultaneously through the suspected infected device and from a peripheral venipuncture. The catheter was removed and its tip cultured semiquantitatively. Catheter-related sepsis occurred in 17 patients. Using as cut-off value a colony count fourfold higher in blood drawn through the catheter than in simultaneously drawn peripheral blood, a sensitivity of 94 %, specificity of 100 % and positive predictive value of 100 % were obtained. A single bacterial count > 100 cfu/ml in the quantitative culture of the catheter blood specimen in the presence of a positive qualitative peripheral blood culture of the same organism was also highly suggestive of catheter-related sepsis. Differential quantitative blood culture is a reliable method for the diagnosis of catheter-associated sepsis without catheter removal. © 1992 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.
Original languageEnglish
Pages (from-to)403-407
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Volume11
Issue number5
DOIs
Publication statusPublished - 1 May 1992

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